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t-Boc-N-amido-PEG4-Val-Cit

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Catalog No. TYD-01998Cas No. 2231240-82-5

t-Boc-N-amido-PEG4-Val-Cit is a protease-cleavable ADC linker, featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit dipeptide. The Val-Cit dipeptide is susceptible to cleavage by cellular proteases and contains a free carboxylic acid that can couple with amines to form amides. The Boc group can be removed under acidic conditions to reveal a free primary amine, which is useful for various reactions, such as conjugation or reductive amination.

t-Boc-N-amido-PEG4-Val-Cit

t-Boc-N-amido-PEG4-Val-Cit

😃Good
Catalog No. TYD-01998Cas No. 2231240-82-5
t-Boc-N-amido-PEG4-Val-Cit is a protease-cleavable ADC linker, featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit dipeptide. The Val-Cit dipeptide is susceptible to cleavage by cellular proteases and contains a free carboxylic acid that can couple with amines to form amides. The Boc group can be removed under acidic conditions to reveal a free primary amine, which is useful for various reactions, such as conjugation or reductive amination.
Pack SizePriceAvailabilityQuantity
10 mgInquiry10-14 weeks
50 mgInquiry10-14 weeks
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Product Introduction

Bioactivity
Description
t-Boc-N-amido-PEG4-Val-Cit is a protease-cleavable ADC linker, featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit dipeptide. The Val-Cit dipeptide is susceptible to cleavage by cellular proteases and contains a free carboxylic acid that can couple with amines to form amides. The Boc group can be removed under acidic conditions to reveal a free primary amine, which is useful for various reactions, such as conjugation or reductive amination.
Chemical Properties
Molecular Weight621.721
FormulaC27H51N5O11
Cas No.2231240-82-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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