Fradafiban

Name: Fradafiban
Brand: TargetMol
SKU: T11322
Rating: 4.5 (1 reviews)

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Catalog No. T11322Cas No. 148396-36-5

Alias BIBU-52

Fradafiban binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM. Fradafiban is a non-polypeptide platelet glycoprotein IIb/IIIa antagonist.

Fradafiban

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Catalog No. T11322Alias BIBU-52Cas No. 148396-36-5

Fradafiban binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM. Fradafiban is a non-polypeptide platelet glycoprotein IIb/IIIa antagonist.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,820	10-14 weeks	10-14 weeks
50 mg	$2,380	10-14 weeks	10-14 weeks
100 mg	$3,100	10-14 weeks	10-14 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	Fradafiban binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM. Fradafiban is a non-polypeptide platelet glycoprotein IIb/IIIa antagonist.
Targets&IC50	GP IIb/IIIa complex (human platelet):(kd)148 nM
In vitro	Fradafiban binds with high affinity and selectivity to the human platelet GP IIb/IIIa complex and potently inhibits human platelet aggregation in vitro.?Fradafiban reversibly binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM.?Fradafiban is a nonpeptide mimetic of the arginine-glycine-aspartic acid recognition sequence.
In vivo	Fradafiban exhibits limited oral activity, likely attributed to its high polarity, which results in poor absorption following oral ingestion.
Synonyms	BIBU-52

Chemical Properties

Molecular Weight	367.40
Formula	C₂₀H₂₁N₃O₄
Cas No.	148396-36-5
Smiles	O(C[C@@H]1C[C@@H](CC(O)=O)C(=O)N1)C2=CC=C(C=C2)C3=CC=C(C(=N)N)C=C3
Relative Density.	1.38g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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