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Sematilide hydrochloride

Name: Sematilide hydrochloride
Brand: TargetMol
SKU: T3574
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3574Cas No. 101526-62-9

Alias Sematilide HCl, CK-1752A, CK-1752

Sematilide hydrochloride (CK-1752) is a class III antiarrhythmic. It is a selectively delayed rectifier K+ current (IKr) channel blocker. It inhibits rapidly activating Ik in guinea pig atrial myocytes, resulting in the prolongation of refractoriness and action potential duration.

Sematilide hydrochloride

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Purity: 99.14%

Catalog No. T3574Alias Sematilide HCl, CK-1752A, CK-1752Cas No. 101526-62-9

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$43	In Stock	In Stock
10 mg	$68	In Stock	In Stock
25 mg	$137	In Stock	In Stock
50 mg	$223	In Stock	In Stock
100 mg	$358	In Stock	In Stock
200 mg	$497	-	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.14%

Appearance:Solid

Color:Red

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COA HNMR LCMS

Product Introduction

Sematilide hydrochloride AI Summary

Sematilide hydrochloride exhibits multiple bioactivities relevant to cardiac electrophysiology. It increases the action potential duration at 95% repolarization (APD95) of canine Purkinje fibers in vitro with a C20 APD95 of 3.5 µM, and also increases the functional refractory period (FRP) of canine ventricular muscle with a C20 FRP of 17.0 µM. It demonstrates efficacy in blocking sustained ventricular tachycardia in anesthetized dogs via intravenous administration, with an efficacy rating of 4.0, and in conscious dogs following oral administration after intravenous administration, with an efficacy rating of 5.0. The compound has pKa values of 7.6 and 9.51, an acute toxicity with an LD50 of 250.0 mg/kg when administered intraperitoneally in mice, and a bioavailability of 41.0% after oral administration in dogs. The half-life (T1/2) of Sematilide hydrochloride is 2.7 hours..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Sematilide hydrochloride (CK-1752) is a class III antiarrhythmic. It is a selectively delayed rectifier K+ current (IKr) channel blocker. It inhibits rapidly activating Ik in guinea pig atrial myocytes, resulting in the prolongation of refractoriness and action potential duration.
Targets&IC50	K+ current:25 μM (IC50)
Synonyms	Sematilide HCl, CK-1752A, CK-1752

Chemical Properties

Molecular Weight	349.87
Formula	C₁₄H₂₄ClN₃O₃S
Cas No.	101526-62-9
Smiles	Cl.CCN(CC)CCNC(=O)c1ccc(NS(C)(=O)=O)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (157.2 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1 mg/mL (2.86 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8582 mL	14.2910 mL	28.5820 mL	142.9102 mL
5 mM	0.5716 mL	2.8582 mL	5.7164 mL	28.5820 mL
10 mM	0.2858 mL	1.4291 mL	2.8582 mL	14.2910 mL
20 mM	0.1429 mL	0.7146 mL	1.4291 mL	7.1455 mL
50 mM	0.0572 mL	0.2858 mL	0.5716 mL	2.8582 mL
100 mM	0.0286 mL	0.1429 mL	0.2858 mL	1.4291 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc