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Siglec-7 Protein,Human,Recombinant (aa 19-353, His)
(Synonyms: siglec-7, Siglec7, sialic acid-binding Ig-like lectin 7, sialic acid binding Ig-like lectin 7, QA79, p75/AIRM1, p75, D-siglec, CDw328, CD328 antigen, CD328, AIRM1QA79 membrane protein, AIRM-1, AIRM1) Copy Product InfoSynonyms: siglec-7, Siglec7, sialic acid-binding Ig-like lectin 7, sialic acid binding Ig-like lectin 7, QA79, p75/AIRM1, p75, D-siglec, CDw328, CD328 antigen, CD328, AIRM1QA79 membrane protein, AIRM-1, AIRM1
Catalog No. TMPJ-01397 Copy Product Info
Siglecs (sialic acid binding Ig-like lectins) are I-type (Ig-type) lectins belonging to the Ig superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains. Eleven human Siglecs have been cloned and characterized. Human Siglec-7 encodes a 467 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N-terminal Ig-like V-type domain, two Ig-like C2-type domains, a transmembrane region and a cytoplasmic tail. Siglec-7 exists as a monomer on the cell surface and is expressed on natural killer cells, CD8+ T cells and monocytes. It binds equally well to both alpha 2,3- and alpha 2,6-linked sialic acid. The gene encoding Siglec-7 was mapped to chromosome 19q13.3.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 µg | $138 | 7-10 days | 7-10 days | |
| 10 µg | $228 | 7-10 days | 7-10 days | |
| 20 µg | $365 | 7-10 days | 7-10 days | |
| 50 µg | $687 | 7-10 days | 7-10 days | |
| 100 µg | $987 | 7-10 days | 7-10 days | |
| 200 µg | $1,490 | 7-10 days | 7-10 days | |
| 500 µg | $2,510 | 7-10 days | 7-10 days | |
| 1 mg | $3,790 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
| Description | Siglecs (sialic acid binding Ig-like lectins) are I-type (Ig-type) lectins belonging to the Ig superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains. Eleven human Siglecs have been cloned and characterized. Human Siglec-7 encodes a 467 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N-terminal Ig-like V-type domain, two Ig-like C2-type domains, a transmembrane region and a cytoplasmic tail. Siglec-7 exists as a monomer on the cell surface and is expressed on natural killer cells, CD8+ T cells and monocytes. It binds equally well to both alpha 2,3- and alpha 2,6-linked sialic acid. The gene encoding Siglec-7 was mapped to chromosome 19q13.3. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | C-6xHis |
| Accession Number | Q9Y286 |
| Amino Acid | Gln19-Leu353 |
| Construction | Gln19-Leu353 |
| Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
| Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. |
| Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Synonyms | siglec-7, Siglec7, sialic acid-binding Ig-like lectin 7, sialic acid binding Ig-like lectin 7, QA79, p75/AIRM1, p75, D-siglec, CDw328, CD328 antigen, CD328, AIRM1QA79 membrane protein, AIRM-1, AIRM1 |
| Research Background | Siglecs (sialic acid binding Ig-like lectins) are I-type (Ig-type) lectins belonging to the Ig superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains. Eleven human Siglecs have been cloned and characterized. Human Siglec-7 encodes a 467 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N-terminal Ig-like V-type domain, two Ig-like C2-type domains, a transmembrane region and a cytoplasmic tail. Siglec-7 exists as a monomer on the cell surface and is expressed on natural killer cells, CD8+ T cells and monocytes. It binds equally well to both alpha 2,3- and alpha 2,6-linked sialic acid. The gene encoding Siglec-7 was mapped to chromosome 19q13.3. |
| Molecular Weight | 50-70 KDa (reducing condition) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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Related Tags: Siglec-7 Protein,Human,Recombinant (aa 19-353, His) chemical structure | Siglec-7 Protein,Human,Recombinant (aa 19-353, His) molecular weight
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