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Siglec-7 Protein,Human,Recombinant(aa 19-353, His）

Catalog No. TMPJ-01397
Synonyms: AIRM1, p75/AIRM1, CD328 antigen, CD328, AIRM-1, siglec-7, QA79, p75, sialic acid binding Ig-like lectin 7, sialic acid-binding Ig-like lectin 7, D-siglec, CDw328, AIRM1QA79 membrane protein, Siglec7

Siglecs (sialic acid binding Ig-like lectins) are I-type (Ig-type) lectins belonging to the Ig superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains. Eleven human Siglecs have been cloned and characterized. Human Siglec-7 encodes a 467 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N-terminal Ig-like V-type domain, two Ig-like C2-type domains, a transmembrane region and a cytoplasmic tail. Siglec-7 exists as a monomer on the cell surface and is expressed on natural killer cells, CD8+ T cells and monocytes. It binds equally well to both alpha 2,3- and alpha 2,6-linked sialic acid. The gene encoding Siglec-7 was mapped to chromosome 19q13.3.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Siglec-7 Protein,Human,Recombinant(aa 19-353, His）
Pack Size Availability Price/USD Quantity
10 μg 5 days $ 228.00
50 μg 5 days $ 687.00
500 μg 5 days $ 2,510.00
1 mg 5 days $ 3,790.00
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Biological Description
Technical Params
Product Properties
Description Siglecs (sialic acid binding Ig-like lectins) are I-type (Ig-type) lectins belonging to the Ig superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains. Eleven human Siglecs have been cloned and characterized. Human Siglec-7 encodes a 467 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N-terminal Ig-like V-type domain, two Ig-like C2-type domains, a transmembrane region and a cytoplasmic tail. Siglec-7 exists as a monomer on the cell surface and is expressed on natural killer cells, CD8+ T cells and monocytes. It binds equally well to both alpha 2,3- and alpha 2,6-linked sialic acid. The gene encoding Siglec-7 was mapped to chromosome 19q13.3.
Species Human
Expression System Human Cells
Tag C-6His
Accession Number Q9Y286
Synonyms AIRM1, p75/AIRM1, CD328 antigen, CD328, AIRM-1, siglec-7, QA79, p75, sialic acid binding Ig-like lectin 7, sialic acid-binding Ig-like lectin 7, D-siglec, CDw328, AIRM1QA79 membrane protein, Siglec7
Amino Acid Gln19-Leu353
Construction Recombinant Human Sialic Acid-binding Ig-like Lectin 7 is produced by our Mammalian expression system and the target gene encoding Gln19-Leu353 is expressed with a 6His tag at the C-terminus.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 50-70 KDa, reducing conditions
Endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
Stability & Storage

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Research Background Siglecs (sialic acid binding Ig-like lectins) are I-type (Ig-type) lectins belonging to the Ig superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains. Eleven human Siglecs have been cloned and characterized. Human Siglec-7 encodes a 467 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N-terminal Ig-like V-type domain, two Ig-like C2-type domains, a transmembrane region and a cytoplasmic tail. Siglec-7 exists as a monomer on the cell surface and is expressed on natural killer cells, CD8+ T cells and monocytes. It binds equally well to both alpha 2,3- and alpha 2,6-linked sialic acid. The gene encoding Siglec-7 was mapped to chromosome 19q13.3.

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Keywords

Siglec-7 Protein,Human,Recombinant(aa 19-353, His） AIRM1 p75/AIRM1 CD328 antigen CD 328 CD328 AIRM-1 siglec-7 QA 79 QA79 p75 sialic acid binding Ig-like lectin 7 CD-328 sialic acid-binding Ig-like lectin 7 D-siglec AIRM 1 CDw328 QA-79 AIRM1QA79 membrane protein Siglec7 recombinant recombinant-proteins proteins protein

 

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