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Calycanthine
🥰Excellent
Catalog No. TN1063Cas No. 595-05-1
Calycanthine is a natural alkaloid exhibiting central nervous system toxicity, capable of inducing convulsions and seizures.
Calycanthine
🥰Excellent
Purity: 99.97%
Catalog No. TN1063Cas No. 595-05-1
Calycanthine is a natural alkaloid exhibiting central nervous system toxicity, capable of inducing convulsions and seizures.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $138 | - | In Stock | |
| 5 mg | $349 | - | In Stock | |
| 10 mg | $596 | - | In Stock | |
| 25 mg | $933 | - | In Stock | |
| 50 mg | $1,250 | - | In Stock | |
| 100 mg | $1,690 | - | In Stock | |
| 200 mg | $2,280 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.97%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Calycanthine is a natural alkaloid exhibiting central nervous system toxicity, capable of inducing convulsions and seizures. |
| In vitro | Calycanthine blocked the L-type calcium currents with an IC(50) of approximately 42 microM and also weakly inhibited the N-type calcium currents (IC(50) > 100 microM) from neuroblastoma X glioma cells, suggesting voltage-dependent calcium channel blockade as a possible mechanism for its inhibition of GABA and ACh release. Calycanthine was also found to directly inhibit GABA-mediated currents (K(B) approximately 135 microM) from human alpha(1)beta(2)gamma(2L) GABA(A) receptors expressed in Xenopus laevis oocytes but had no effect at 100 microM on human rho(1) GABA(c) receptors [1]. |
| Molecular Weight | 346.47 |
| Formula | C22H26N4 |
| Cas No. | 595-05-1 |
| Smiles | [H][C@@]12Nc3ccccc3[C@]3(CCN1C)[C@]1([H])Nc4ccccc4[C@]23CCN1C |
| Relative Density. | 1.29g/cm3 |
| Color | Yellow |
| Appearance | Solid |
Storage & Solubility Information
| Storage | keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (230.9 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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