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KIF18A-IN-2

Name: KIF18A-IN-2
Brand: TargetMol
SKU: T60026
Price: 68 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T60026Cas No. 2600559-20-2

KIF18A-IN-2 is an inhibitor of mitotic kinesin Kif18A with IC50 of 28 nM and can be used in studies about chromosomal instability-associated vulnerabilities.

KIF18A-IN-2

🥰Excellent

Purity: 99.64%

Catalog No. T60026Cas No. 2600559-20-2

KIF18A-IN-2 is an inhibitor of mitotic kinesin Kif18A with IC50 of 28 nM and can be used in studies about chromosomal instability-associated vulnerabilities.

Pack Size	Price	Availability
1 mg	$68	In Stock
5 mg	$175	In Stock
10 mg	$257	In Stock
25 mg	$403	In Stock
50 mg	$533	In Stock
100 mg	$708	In Stock
200 mg	$958	In Stock
1 mL x 10 mM (in DMSO)	$212	In Stock

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Batch Information

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Purity:99.64%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	KIF18A-IN-2 is an inhibitor of mitotic kinesin Kif18A with IC50 of 28 nM and can be used in studies about chromosomal instability-associated vulnerabilities.
In vivo	In Female athymic nude mice injected with human OVCAR-3 HGSOC cells, KIF18A-IN-2 (100 mg/kg; i.p.) exhibits a significant and sustained pharmacodynamic response and increases the number of mitotic cells (pH3 positive cells) in tumor tissues[1].

Chemical Properties

Molecular Weight	534.69
Formula	C₂₅H₃₄N₄O₅S₂
Cas No.	2600559-20-2
Smiles	CC(C)(C)NS(=O)(=O)c1cccc(NC(=O)c2ccc(NS(C)(=O)=O)cc2N2CCC3(CC3)CC2)c1

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (102.86 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8702 mL	9.3512 mL	18.7024 mL	93.5121 mL
5 mM	0.3740 mL	1.8702 mL	3.7405 mL	18.7024 mL
10 mM	0.1870 mL	0.9351 mL	1.8702 mL	9.3512 mL
20 mM	0.0935 mL	0.4676 mL	0.9351 mL	4.6756 mL
50 mM	0.0374 mL	0.1870 mL	0.3740 mL	1.8702 mL
100 mM	0.0187 mL	0.0935 mL	0.1870 mL	0.9351 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc