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suvn-911

Name: suvn-911
Brand: TargetMol
SKU: T9787
Price: 65 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9787Cas No. 2414674-71-6

suvn-911 is a potent and selective antagonist of neuronal nicotinic acetylcholine α4β2 receptor (Ki = 1.5 nM) with antidepressant activity.

suvn-911

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Purity: 98.88%

Catalog No. T9787Cas No. 2414674-71-6

suvn-911 is a potent and selective antagonist of neuronal nicotinic acetylcholine α4β2 receptor (Ki = 1.5 nM) with antidepressant activity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$65	In Stock	In Stock
5 mg	$143	In Stock	In Stock
10 mg	$227	In Stock	In Stock
25 mg	$377	In Stock	In Stock
50 mg	$536	In Stock	In Stock
100 mg	$732	In Stock	In Stock
200 mg	$986	In Stock	-
1 mL x 10 mM (in DMSO)	$191	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.88%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	suvn-911 is a potent and selective antagonist of neuronal nicotinic acetylcholine α4β2 receptor (Ki = 1.5 nM) with antidepressant activity.
Targets&IC50	α4β2 nAChR:1.5 nM(Ki)
In vitro	SUVN-911 demonstrates high selectivity towards α4β2 over α3β4 nACh receptors, standing out against a broad spectrum of over 70 targets, including GPCRs, ion channels, enzymes, peptides, steroids, second messengers, growth factors, and prostaglandins. This specificity underscores its promising potential in targeted pharmacological applications.
In vivo	In male Wistar rats, suvn-911 (1.0-10.0 mg/kg; p.o.) showed significant antidepressant-like activity with no signs of tachyphylaxis. suvn-911 (3 mg/kg; p.o.) showed high oral exposures, longer half-lives(T1/2 = 3.34 hr), and adequate brain penetration in Wistar rats. suvn-911 showed metabolic stability and no cardiovascular and gastrointestinal side effects[1].

Chemical Properties

Molecular Weight	261.15
Formula	C₁₁H₁₄Cl₂N₂O
Cas No.	2414674-71-6
Smiles	Cl.Clc1ccc(OC[C@@H]2C[C@H]3C[C@H]3N2)cn1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (191.46 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8292 mL	19.1461 mL	38.2922 mL	191.4608 mL
5 mM	0.7658 mL	3.8292 mL	7.6584 mL	38.2922 mL
10 mM	0.3829 mL	1.9146 mL	3.8292 mL	19.1461 mL
20 mM	0.1915 mL	0.9573 mL	1.9146 mL	9.5730 mL
50 mM	0.0766 mL	0.3829 mL	0.7658 mL	3.8292 mL
100 mM	0.0383 mL	0.1915 mL	0.3829 mL	1.9146 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc