Powder: -20°C for 3 years | In solvent: -80°C for 1 year
suvn-911 is a potent and selective antagonist of neuronal nicotinic acetylcholine α4β2 receptor (Ki = 1.5 nM) with antidepressant activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 135.00 | |
5 mg | In stock | $ 289.00 | |
10 mg | In stock | $ 478.00 | |
25 mg | In stock | $ 789.00 | |
50 mg | In stock | $ 1,080.00 | |
100 mg | In stock | $ 1,480.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 393.00 |
Description | suvn-911 is a potent and selective antagonist of neuronal nicotinic acetylcholine α4β2 receptor (Ki = 1.5 nM) with antidepressant activity. |
Targets&IC50 | α4β2 nAChR:1.5 nM(Ki) |
In vitro | SUVN-911 demonstrates high selectivity towards α4β2 over α3β4 nACh receptors, standing out against a broad spectrum of over 70 targets, including GPCRs, ion channels, enzymes, peptides, steroids, second messengers, growth factors, and prostaglandins. This specificity underscores its promising potential in targeted pharmacological applications. |
In vivo | In male Wistar rats, suvn-911 (1.0-10.0 mg/kg; p.o.) showed significant antidepressant-like activity with no signs of tachyphylaxis. suvn-911 (3 mg/kg; p.o.) showed high oral exposures, longer half-lives(T1/2 = 3.34 hr), and adequate brain penetration in Wistar rats. suvn-911 showed metabolic stability and no cardiovascular and gastrointestinal side effects[1]. |
Molecular Weight | 224.69 |
Formula | C11H13ClN2O |
CAS No. | 2414674-71-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (222.53 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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