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suvn-911

Name: suvn-911
Brand: TargetMol
SKU: T9787
Price: 65 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9787Cas No. 2414674-71-6

suvn-911 is a potent and selective antagonist of neuronal nicotinic acetylcholine α4β2 receptor (Ki = 1.5 nM) with antidepressant activity.

suvn-911

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Purity: 98.88%

Catalog No. T9787Cas No. 2414674-71-6

suvn-911 is a potent and selective antagonist of neuronal nicotinic acetylcholine α4β2 receptor (Ki = 1.5 nM) with antidepressant activity.

Pack Size	Price	Availability
1 mg	$65	In Stock
5 mg	$143	In Stock
10 mg	$227	In Stock
25 mg	$377	In Stock
50 mg	$536	In Stock
100 mg	$732	In Stock
200 mg	$986	In Stock
1 mL x 10 mM (in DMSO)	$191	In Stock

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Purity:98.88%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	suvn-911 is a potent and selective antagonist of neuronal nicotinic acetylcholine α4β2 receptor (Ki = 1.5 nM) with antidepressant activity.
Targets&IC50	α4β2 nAChR:1.5 nM(Ki)
In vitro	SUVN-911 demonstrates high selectivity towards α4β2 over α3β4 nACh receptors, standing out against a broad spectrum of over 70 targets, including GPCRs, ion channels, enzymes, peptides, steroids, second messengers, growth factors, and prostaglandins. This specificity underscores its promising potential in targeted pharmacological applications.
In vivo	In male Wistar rats, suvn-911 (1.0-10.0 mg/kg; p.o.) showed significant antidepressant-like activity with no signs of tachyphylaxis. suvn-911 (3 mg/kg; p.o.) showed high oral exposures, longer half-lives(T1/2 = 3.34 hr), and adequate brain penetration in Wistar rats. suvn-911 showed metabolic stability and no cardiovascular and gastrointestinal side effects[1].

Chemical Properties

Molecular Weight	261.15
Formula	C₁₁H₁₄Cl₂N₂O
Cas No.	2414674-71-6
Smiles	Cl.Clc1ccc(OC[C@@H]2C[C@H]3C[C@H]3N2)cn1
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50.00 mg/mL (191.46 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8292 mL	19.1461 mL	38.2922 mL	191.4608 mL
5 mM	0.7658 mL	3.8292 mL	7.6584 mL	38.2922 mL
10 mM	0.3829 mL	1.9146 mL	3.8292 mL	19.1461 mL
20 mM	0.1915 mL	0.9573 mL	1.9146 mL	9.5730 mL
50 mM	0.0766 mL	0.3829 mL	0.7658 mL	3.8292 mL
100 mM	0.0383 mL	0.1915 mL	0.3829 mL	1.9146 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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