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WWL 154

Name: WWL 154
Brand: TargetMol
SKU: T8927
Price: 36 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8927Cas No. 1338574-93-8

Alias WWL-154

WWL 154 is an serine hydrolase (SH) and fatty acid amide hydrolase FAAH-4 inhibitor.

WWL 154

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Purity: 99.22%

Catalog No. T8927Alias WWL-154Cas No. 1338574-93-8

WWL 154 is an serine hydrolase (SH) and fatty acid amide hydrolase FAAH-4 inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$36	In Stock	In Stock
5 mg	$53	In Stock	In Stock
10 mg	$76	In Stock	In Stock
25 mg	$107	In Stock	In Stock
50 mg	$153	In Stock	In Stock
100 mg	$230	In Stock	In Stock
200 mg	$327	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$54	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.22%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR HPLC

Product Introduction

WWL 154 AI Summary

WWL 154 demonstrates bioactivity as an inhibitor across various assays. It inhibits glutaminase (GLS) with a potency of 14125.4 nM and acts as an inverse agonist of the GLP-1 receptor with a potency of 10000.0 nM. It exhibits inhibitory effects on human tyrosyl-DNA phosphodiesterase 1 (TDP1) with potencies of 25929.0 nM without CPT present and 29092.9 nM with CPT present in cells. The compound also inhibits TDP-43 with a potency of 6309.6 nM and PTHR with a potency of 50118.7 nM. Additionally, it shows activity against AMA1-RON for antimalarial drug development with a potency of 7079.5 nM and acts as an antiviral against Foot and Mouth Disease Virus with a potency of 44668.4 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	WWL 154 is an serine hydrolase (SH) and fatty acid amide hydrolase FAAH-4 inhibitor.
Synonyms	WWL-154

Chemical Properties

Molecular Weight	357.36
Formula	C₁₈H₁₉N₃O₅
Cas No.	1338574-93-8
Smiles	COc1ccc(cc1)N1CCN(CC1)C(=O)Oc1ccc(cc1)[N+]([O-])=O
Relative Density.	1.315 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (69.96 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7983 mL	13.9915 mL	27.9830 mL	139.9149 mL
5 mM	0.5597 mL	2.7983 mL	5.5966 mL	27.9830 mL
10 mM	0.2798 mL	1.3991 mL	2.7983 mL	13.9915 mL
20 mM	0.1399 mL	0.6996 mL	1.3991 mL	6.9957 mL
50 mM	0.0560 mL	0.2798 mL	0.5597 mL	2.7983 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc