DPPE-PEG750 is a PEG lipid functional end group used for synthesizing liposomes (LPs) and designing conjugated polymer nanoparticles. Liposome nanoparticles (LNPs) modified with biotin and carboxylic ends can couple with other biomolecules. These functionalized nanoparticles are useful for targeting specific cell proteins. Using streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles can bind to biotinylated antibodies on cell surface receptors, facilitating fluorescence-based imaging and sensing applications.