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Fevipiprant

Name: Fevipiprant
Brand: TargetMol
SKU: T3965
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3965Cas No. 872365-14-5

Alias QAW039, NVP-QAW039

Fevipiprant (NVP-QAW039) is a selective, potent, reversible competitive CRTh2 antagonist.

Fevipiprant

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Purity: 99.59%

Catalog No. T3965Alias QAW039, NVP-QAW039Cas No. 872365-14-5

Fevipiprant (NVP-QAW039) is a selective, potent, reversible competitive CRTh2 antagonist.

Pack Size	Price	Availability
5 mg	$29	In Stock
10 mg	$43	In Stock
25 mg	$88	In Stock
50 mg	$137	In Stock
100 mg	$223	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Purity:99.59%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Fevipiprant (NVP-QAW039) is a selective, potent, reversible competitive CRTh2 antagonist.
Targets&IC50	DP2:1.14 nM (Kd), CRTH2:0.44 nM
In vitro	CRTh2-mediated shape change in eosinophils was used to profile QAW039 in whole blood and represents a physiologically relevant environment. The comparable IC50 values for QAW039 in the whole blood and isolated shape-change assays are consistent with its lower plasma-protein binding and its relatively slow dissociation kinetics that drive its increased potency .QAW039 is highly potent in whole-blood systems, with the IC50 value obtained consistent with the affinity values calculated from radioligand experiments. In a further disease-relevant cellular context, the potency of QAW039 in the isolated Th2 cell cytokine inhibition assay is consistent with its CRTh2 receptor affinity, and, as with eosinophil assay readouts, this represents an improved potency compared with QAV680.[
Synonyms	QAW039, NVP-QAW039

Chemical Properties

Molecular Weight	426.41
Formula	C₁₉H₁₇F₃N₂O₄S
Cas No.	872365-14-5
Smiles	Cc1c(CC(O)=O)c2cccnc2n1Cc1ccc(cc1C(F)(F)F)S(C)(=O)=O
Relative Density.	1.44 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (140.71 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3452 mL	11.7258 mL	23.4516 mL	117.2580 mL
5 mM	0.4690 mL	2.3452 mL	4.6903 mL	23.4516 mL
10 mM	0.2345 mL	1.1726 mL	2.3452 mL	11.7258 mL
20 mM	0.1173 mL	0.5863 mL	1.1726 mL	5.8629 mL
50 mM	0.0469 mL	0.2345 mL	0.4690 mL	2.3452 mL
100 mM	0.0235 mL	0.1173 mL	0.2345 mL	1.1726 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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