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Fevipiprant

Name: Fevipiprant
Brand: TargetMol
SKU: T3965
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3965Cas No. 872365-14-5

Alias QAW039, NVP-QAW039

Fevipiprant (NVP-QAW039) is a selective, potent, reversible competitive CRTh2 antagonist.

Fevipiprant

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Purity: 99.59%

Catalog No. T3965Alias QAW039, NVP-QAW039Cas No. 872365-14-5

Fevipiprant (NVP-QAW039) is a selective, potent, reversible competitive CRTh2 antagonist.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$29	In Stock	In Stock
10 mg	$43	In Stock	In Stock
25 mg	$88	In Stock	In Stock
50 mg	$137	In Stock	In Stock
100 mg	$223	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.59%

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Fevipiprant (NVP-QAW039) is a selective, potent, reversible competitive CRTh2 antagonist.
Targets&IC50	DP2:1.14 nM (Kd), CRTH2:0.44 nM
In vitro	CRTh2-mediated shape change in eosinophils was used to profile QAW039 in whole blood and represents a physiologically relevant environment. The comparable IC50 values for QAW039 in the whole blood and isolated shape-change assays are consistent with its lower plasma-protein binding and its relatively slow dissociation kinetics that drive its increased potency .QAW039 is highly potent in whole-blood systems, with the IC50 value obtained consistent with the affinity values calculated from radioligand experiments. In a further disease-relevant cellular context, the potency of QAW039 in the isolated Th2 cell cytokine inhibition assay is consistent with its CRTh2 receptor affinity, and, as with eosinophil assay readouts, this represents an improved potency compared with QAV680.[
Synonyms	QAW039, NVP-QAW039

Chemical Properties

Molecular Weight	426.41
Formula	C₁₉H₁₇F₃N₂O₄S
Cas No.	872365-14-5
Smiles	Cc1c(CC(O)=O)c2cccnc2n1Cc1ccc(cc1C(F)(F)F)S(C)(=O)=O
Relative Density.	1.44 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (140.71 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.69 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3452 mL	11.7258 mL	23.4516 mL	117.2580 mL
5 mM	0.4690 mL	2.3452 mL	4.6903 mL	23.4516 mL
10 mM	0.2345 mL	1.1726 mL	2.3452 mL	11.7258 mL
20 mM	0.1173 mL	0.5863 mL	1.1726 mL	5.8629 mL
50 mM	0.0469 mL	0.2345 mL	0.4690 mL	2.3452 mL
100 mM	0.0235 mL	0.1173 mL	0.2345 mL	1.1726 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc