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LY377604

Name: LY377604
Brand: TargetMol
SKU: T15819
Price: 127 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15819Cas No. 204592-94-9

LY377604 is a human β3-adrenergic receptor agonist (EC50: 2.4 nM) and β1/2-adrenergic receptor antagonist for the study of obesity.

LY377604

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Purity: 99.72%

Catalog No. T15819Cas No. 204592-94-9

LY377604 is a human β3-adrenergic receptor agonist (EC50: 2.4 nM) and β1/2-adrenergic receptor antagonist for the study of obesity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$127	-	In Stock
5 mg	$318	-	In Stock
10 mg	$472	-	In Stock
25 mg	$773	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.72%

ee:100%

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COA CSFC HNMR LCMS

Product Introduction

Bioactivity

Description	LY377604 is a human β3-adrenergic receptor agonist (EC50: 2.4 nM) and β1/2-adrenergic receptor antagonist for the study of obesity.
Targets&IC50	β3-adrenoceptor (human):2.4 nM (EC50)
In vitro	LY377604 is a β1- and β2-adrenergic receptor antagonist as well as a β3-adrenergic receptor agonist, causing a maximal increase in cyclic adenosine monophosphate (cAMP) levels with an EC50 of 2.4 nM[1].
In vivo	LY377604 administered orally at 10mg/kg increases diet-induced obesity in male Long-Evans rats by enhancing calorie expenditure[1].

Chemical Properties

Molecular Weight	524.61
Formula	C₃₁H₃₂N₄O₄
Cas No.	204592-94-9
Smiles	O(C[C@H](CNC(CC1=CC=C(OC2=CC=C(C(N)=O)C=N2)C=C1)(C)C)O)C3=C4C=5C(NC4=CC=C3)=CC=CC5
Relative Density.	1.282 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (152.49 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.29 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9062 mL	9.5309 mL	19.0618 mL	95.3089 mL
5 mM	0.3812 mL	1.9062 mL	3.8124 mL	19.0618 mL
10 mM	0.1906 mL	0.9531 mL	1.9062 mL	9.5309 mL
20 mM	0.0953 mL	0.4765 mL	0.9531 mL	4.7654 mL
50 mM	0.0381 mL	0.1906 mL	0.3812 mL	1.9062 mL
100 mM	0.0191 mL	0.0953 mL	0.1906 mL	0.9531 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc