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XmAb 5592
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Catalog No. T80762 Copy Product Info
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XmAb 5592 is a Fc-engineered and humanized anti-HM1.24 antibody with anti-tumor activity, used in the study of multiple myeloma.
Cas No. 1221901-33-2
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $183 | - | In Stock | |
| 5 mg | $496 | - | In Stock | |
| 10 mg | $795 | - | In Stock | |
| 25 mg | $1,180 | - | In Stock | |
| 50 mg | $1,580 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.51% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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| Description | XmAb 5592 is a Fc-engineered and humanized anti-HM1.24 antibody with anti-tumor activity, used in the study of multiple myeloma. |
| Targets & IC50 | HM1.24:1.5 nM (Kd) |
| In vitro | XmAb5592 binds to HM1.24 with high binding affinity and Kd value of 1.5 nM. XmAb 5592 enhanced antibody-dependent cytotoxicity (ADCC) and antibody-dependent cytophagocytosis (ADCP) against multiple myeloma (MM) cells at concentrations ranging from 0 to 1000 ng/mL. XmAb5592 significantly enhanced the cleavage of MM cell lines and significantly increased the maximum cleavage efficiency (EC50 range 5-27 ng/mL). [1] |
| In vivo | SCID mice carrying RPMI8226 subcutaneous tumors were treated twice weekly with 0.9, 3.0, or 9.0 mg/kg of XmAb 5592, which inhibited RPMI8226 tumor growth in a dose-dependent manner. Its antitumor activity is mediated by an Fgamra-dependent mechanism. A single intravenous infusion of XmAb5592 at 20 mg/kg showed that a single dose of XmAb5592 depleted plasma cells in cymavores' blood and BM compartms. [1] |
| Reactivity | Human |
| Verified Activity | Immobilized Human BST2 Protein (His) (TMPY-03235) at 1 μg/mL (100 μL/well) can bind XmAb 5592. The EC50 is 1.42 ng/mL.  |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | BST2/CD317 |
| Molecular Weight | 145.80 kDa |
| Cas No. | 1221901-33-2 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | Store at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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Related Tags: XmAb 5592 chemical structure | XmAb 5592 in vivo | XmAb 5592 in vitro | XmAb 5592 molecular weight
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