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XmAb 5592
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Catalog No. T80762Cas No. 1221901-33-2
XmAb 5592 is a Fc-engineered and humanized anti-HM1.24 antibody with anti-tumor activity, used in the study of multiple myeloma.
XmAb 5592
XmAb 5592
😃Good
Catalog No. T80762Cas No. 1221901-33-2
XmAb 5592 is a Fc-engineered and humanized anti-HM1.24 antibody with anti-tumor activity, used in the study of multiple myeloma.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $183 | - | In Stock | |
| 5 mg | $496 | - | In Stock | |
| 10 mg | $795 | - | In Stock | |
| 25 mg | $1,180 | - | In Stock | |
| 50 mg | $1,580 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.51% (SEC-HPLC)
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Target HM1
Antibody Information
| Description | XmAb 5592 is a Fc-engineered and humanized anti-HM1.24 antibody with anti-tumor activity, used in the study of multiple myeloma. |
| Targets&IC50 | HM1.24:1.5 nM (Kd) |
| In vitro | XmAb5592 binds to HM1.24 with high binding affinity and Kd value of 1.5 nM. XmAb 5592 enhanced antibody-dependent cytotoxicity (ADCC) and antibody-dependent cytophagocytosis (ADCP) against multiple myeloma (MM) cells at concentrations ranging from 0 to 1000 ng/mL. XmAb5592 significantly enhanced the cleavage of MM cell lines and significantly increased the maximum cleavage efficiency (EC50 range 5-27 ng/mL). [1] |
| In vivo | SCID mice carrying RPMI8226 subcutaneous tumors were treated twice weekly with 0.9, 3.0, or 9.0 mg/kg of XmAb 5592, which inhibited RPMI8226 tumor growth in a dose-dependent manner. Its antitumor activity is mediated by an Fgamra-dependent mechanism. A single intravenous infusion of XmAb5592 at 20 mg/kg showed that a single dose of XmAb5592 depleted plasma cells in cymavores' blood and BM compartms. [1] |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | ＜ 1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID |
| Cas No. | 1221901-33-2 |
| Isotype | IgG1 |
Storage & Solubility Information
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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