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ATX inhibitor 5

Name: ATX inhibitor 5
Brand: TargetMol
SKU: T10409
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10409Cas No. 2402772-45-4

ATX inhibitor 5 is a potent and orally active autotaxin (ATX) inhibitor (IC50: 15.3 nM) that reduces CCl4-induced hepatic fibrosis and exhibits anti-hepatic fibrosis effects.

ATX inhibitor 5

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Purity: 99.73%

Catalog No. T10409Cas No. 2402772-45-4

ATX inhibitor 5 is a potent and orally active autotaxin (ATX) inhibitor (IC50: 15.3 nM) that reduces CCl4-induced hepatic fibrosis and exhibits anti-hepatic fibrosis effects.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$41	In Stock	In Stock
5 mg	$100	In Stock	In Stock
10 mg	$161	In Stock	In Stock
25 mg	$273	In Stock	In Stock
50 mg	$375	In Stock	In Stock
100 mg	$512	In Stock	In Stock
200 mg	$690	-	In Stock
1 mL x 10 mM (in DMSO)	$103	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.73%

Resource Download

COA LCMS FNMR HNMR

Product Introduction

Bioactivity

Description	ATX inhibitor 5 is a potent and orally active autotaxin (ATX) inhibitor (IC50: 15.3 nM) that reduces CCl4-induced hepatic fibrosis and exhibits anti-hepatic fibrosis effects.
Targets&IC50	Stellate cells:0.78 μM, ATX:15.3 nM, Fibroblasts (cardiac):1.21 μM
In vitro	ATX inhibitor 5 (10 μM) successfully suppresses collagen content induced by TGF-β.[1]
In vivo	ATX inhibitor 5 (20-40 mg/kg/d, p.o., two weeks) significantly reduces CCl4-induced hepatic fibrosis levels.[1]

Chemical Properties

Molecular Weight	474.87
Formula	C₂₂H₁₈ClF₃N₆O
Cas No.	2402772-45-4
Smiles	FC(F)(F)c1cccc(Nc2ncnc3CCN(Cc23)C(=O)N\N=C\c2ccc(Cl)cc2)c1
Relative Density.	1.45 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 225 mg/mL (473.81 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (6.95 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1058 mL	10.5292 mL	21.0584 mL	105.2920 mL
5 mM	0.4212 mL	2.1058 mL	4.2117 mL	21.0584 mL
10 mM	0.2106 mL	1.0529 mL	2.1058 mL	10.5292 mL
20 mM	0.1053 mL	0.5265 mL	1.0529 mL	5.2646 mL
50 mM	0.0421 mL	0.2106 mL	0.4212 mL	2.1058 mL
100 mM	0.0211 mL	0.1053 mL	0.2106 mL	1.0529 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc