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PROT-IN-1
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Catalog No. T67938Cas No. 329935-45-7
PROT-IN-1 is a potent high-affinity inhibitor of L-proline transporter and a candidate compound for the treatment of neurological diseases.
PROT-IN-1
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Purity: 98.55%
Catalog No. T67938Cas No. 329935-45-7
PROT-IN-1 is a potent high-affinity inhibitor of L-proline transporter and a candidate compound for the treatment of neurological diseases.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $33 | In Stock | In Stock | |
| 10 mg | $54 | In Stock | In Stock | |
| 25 mg | $92 | In Stock | In Stock | |
| 50 mg | $137 | In Stock | In Stock | |
| 100 mg | $203 | In Stock | In Stock | |
| 500 mg | $483 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $39 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information
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Purity:98.55%
Appearance:Solid
Color:White
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Product Introduction
PROT-IN-1 AI Summary
PROT-IN-1 displays multiple bioactivities. It is a potent modulator of miRNAs, particularly activating miR-21, and demonstrates significant inhibitory activity against Bacillus subtilis Sfp PPTase. Furthermore, it acts as an inhibitor targeting the Menin-MLL interaction in MLL-related leukemias and shows inhibitory effects on DNA Polymerase Beta. It also inhibits activity in the Nrf2 qHTS screen and re-activates p53 using a Luc reporter. In human embryonic kidney cells, it inhibits ELG1-dependent DNA repair. Additionally, it exhibits delayed death inhibition of the malarial parasite plastid, inhibits firefly luciferase, and induces DNA re-replication in SW480 colon adenocarcinoma cells. PROT-IN-1 also functions as a TDP-43 inhibitor, inhibits PTHR, and has been screened as a potential antiviral against the Foot and Mouth Disease Virus. Lastly, it inhibits the human high-affinity L-proline transporter expressed in COS1 cells, with an IC50 value of 1480.0 nM as determined through a [3H]proline uptake assay..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | PROT-IN-1 is a potent high-affinity inhibitor of L-proline transporter and a candidate compound for the treatment of neurological diseases. |
| Molecular Weight | 342.43 |
| Formula | C23H22N2O |
| Cas No. | 329935-45-7 |
| Smiles | C(=O)(C1=CC=C(C=C1)C2=CC=CC=C2)N3CCN(CC3)C4=CC=CC=C4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 27.5 mg/mL (80.31 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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