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Carbazeran

Name: Carbazeran
Brand: TargetMol
SKU: T21457
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21457Cas No. 70724-25-3

Alias UK-31557, UK31557, UK-31,557, UK31,557, UK 31557, UK 31,557

Carbazeran (UK-31,557) is an inhibitor of PDE2 and PDE3 and can be used for studies about metabolic diseases. Carbazeran shows inotropic and chronotropic effects in vivo(EC50 = 100 μM).

Carbazeran

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Purity: 99.3%

Catalog No. T21457Alias UK-31557, UK31557, UK-31,557, UK31,557, UK 31557, UK 31,557Cas No. 70724-25-3

Carbazeran (UK-31,557) is an inhibitor of PDE2 and PDE3 and can be used for studies about metabolic diseases. Carbazeran shows inotropic and chronotropic effects in vivo(EC50 = 100 μM).

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$37	In Stock	In Stock
5 mg	$59	In Stock	In Stock
10 mg	$93	In Stock	In Stock
25 mg	$188	In Stock	In Stock
50 mg	$285	In Stock	In Stock
100 mg	$428	-	In Stock
1 mL x 10 mM (in DMSO)	$65	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.3%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Carbazeran AI Summary

Carbazeran exhibits multiple bioactivities, including inhibition of cAMP Phosphodiesterase enzyme and positive inotropic effects through beta-1 adrenergic receptor activation. It has significant pharmacokinetic properties: a plasma clearance rate of 38.0 mL/min/kg in humans, a fraction unbound in plasma of 0.08, and a half-life of 0.01683 hours in human liver S9 fraction with NADPH. Intrinsic clearance rates are 33.88 μL/min/10^6 cells in rat hepatocytes and 64.57 μL/min/10^6 cells in human hepatocytes, suggesting metabolism-related activities. Species-specific pharmacokinetics reveal varying bioavailability and half-life in Hartley guinea pigs and Sprague-Dawley rats, depending on the administration route. The compound has an aldehyde oxidase-mediated retention time of 10.9 minutes in human hepatocytes and shows moderate aldehyde oxidase substrate activity with notable K values in liver cytosol and hepatocytes. Additionally, Carbazeran demonstrates moderate antiviral activity against SARS-CoV-2 with an IC50 value greater than 20000 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Carbazeran (UK-31,557) is an inhibitor of PDE2 and PDE3 and can be used for studies about metabolic diseases. Carbazeran shows inotropic and chronotropic effects in vivo(EC50 = 100 μM).
Synonyms	UK-31557, UK31557, UK-31,557, UK31,557, UK 31557, UK 31,557

Chemical Properties

Molecular Weight	360.41
Formula	C₁₈H₂₄N₄O₄
Cas No.	70724-25-3
Smiles	CCNC(=O)OC1CCN(CC1)c1nncc2cc(OC)c(OC)cc12
Relative Density.	1.27g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (416.19 mM), Sonication is recommended.

H2O: Insoluble

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7746 mL	13.8731 mL	27.7462 mL	138.7309 mL
5 mM	0.5549 mL	2.7746 mL	5.5492 mL	27.7462 mL
10 mM	0.2775 mL	1.3873 mL	2.7746 mL	13.8731 mL
20 mM	0.1387 mL	0.6937 mL	1.3873 mL	6.9365 mL
50 mM	0.0555 mL	0.2775 mL	0.5549 mL	2.7746 mL
100 mM	0.0277 mL	0.1387 mL	0.2775 mL	1.3873 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc