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UNC 1021
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Catalog No. T64375Cas No. 1322591-19-4
UNC 1021 is a selective L3MBTL3 inhibitor (IC50 = 0.048 μM).
UNC 1021
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Purity: 99.91%
Catalog No. T64375Cas No. 1322591-19-4
UNC 1021 is a selective L3MBTL3 inhibitor (IC50 = 0.048 μM).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $38 | In Stock | In Stock | |
| 10 mg | $58 | In Stock | In Stock | |
| 25 mg | $113 | In Stock | In Stock | |
| 50 mg | $178 | In Stock | In Stock | |
| 100 mg | $287 | In Stock | In Stock | |
| 200 mg | $397 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.91%
Appearance:Solid
Color:White
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Product Introduction
UNC 1021 AI Summary
UNC 1021 shows bioactivity related to the inhibition of L3MBTL1 and L3MBTL3, as well as notable binding affinity to these targets. It has an IC50 of 2900.0 nM for L3MBTL1, 71.0 nM for L3MBTL3, and 48.0 nM for L3MBTL3 with H4K20me2 as the substrate. The compound demonstrates selectivity towards L3MBTL3 over L3MBTL1 with a selectivity ratio of 16.0. Additionally, it has a Kd of 6200.0 nM for L3MBTL1 and 390.0 nM for L3MBTL3. It further displays a selectivity ratio of IC50 for L3MBTL1 to IC50 for L3MBTL3 as 41.0..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | UNC 1021 is a selective L3MBTL3 inhibitor (IC50 = 0.048 μM). |
| Molecular Weight | 438.61 |
| Formula | C26H38N4O2 |
| Cas No. | 1322591-19-4 |
| Smiles | O=C(N1CCC(CC1)N1CCCC1)c1ccc(cc1)C(=O)N1CCC(CC1)N1CCCC1 |
| Relative Density. | 1.196 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 9 mg/mL (20.52 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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