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Tenidap

Name: Tenidap
Brand: TargetMol
SKU: T17036
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T17036Cas No. 120210-48-2

Alias CP-66248

Tenidap (CP-66248) is a selective COX-1 and SLC26A3 inhibitor with anti-inflammatory, analgesic, and anti-rheumatic activities.

Tenidap

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Purity: 99.42%

Catalog No. T17036Alias CP-66248Cas No. 120210-48-2

Tenidap (CP-66248) is a selective COX-1 and SLC26A3 inhibitor with anti-inflammatory, analgesic, and anti-rheumatic activities.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
5 mg	$58	In Stock	In Stock
10 mg	$98	In Stock	In Stock
25 mg	$212	In Stock	In Stock
50 mg	$353	In Stock	In Stock
100 mg	$616	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$64	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.42%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Tenidap (CP-66248) is a selective COX-1 and SLC26A3 inhibitor with anti-inflammatory, analgesic, and anti-rheumatic activities.
Targets&IC50	COX-1:0.03 μM, COX-2:1.2 μM
In vitro	The human astrocytoma cell line U373 MG was incubated with 0.1-100 µM tenidap for 30 min and then stimulated with 50 µM C6-ceramide for 24 h. Tenidap inhibited the dose-dependent ceramide-induced IL-6 protein synthesis in U373 human astrocytoma cells.[4]
In vivo	After sustained epilepsy (SE) induced by trichostatin in male Wistar rats, Tenidap was administered at 10 mg / kg daily for 10 days, 46.88 ± 10.70 neurons survived in the tenidap-SE group, and 37.75 ± 8.78 neurons survived in the tenidap-SE group, Tenidap significantly inhibited the hippocampal expression of COX-2 in the hippocampus, especially in the CA3 region.[3]
Synonyms	CP-66248

Chemical Properties

Molecular Weight	320.75
Formula	C₁₄H₉ClN₂O₃S
Cas No.	120210-48-2
Smiles	NC(=O)N1C(=O)\C(=C(/O)c2cccs2)c2cc(Cl)ccc12
Relative Density.	1.648 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (62.35 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1177 mL	15.5885 mL	31.1769 mL	155.8846 mL
5 mM	0.6235 mL	3.1177 mL	6.2354 mL	31.1769 mL
10 mM	0.3118 mL	1.5588 mL	3.1177 mL	15.5885 mL
20 mM	0.1559 mL	0.7794 mL	1.5588 mL	7.7942 mL
50 mM	0.0624 mL	0.3118 mL	0.6235 mL	3.1177 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc