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BAY-545

Name: BAY-545
Brand: TargetMol
SKU: T8512
Price: 81 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8512Cas No. 1699717-32-2

BAY-545 is an antagonist of A2B adenosine receptor(IC50 : 59 nM).

BAY-545

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Purity: 98.05%

Catalog No. T8512Cas No. 1699717-32-2

BAY-545 is an antagonist of A2B adenosine receptor(IC50 : 59 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$81	In Stock	In Stock
5 mg	$173	In Stock	In Stock
10 mg	$260	In Stock	In Stock
25 mg	$467	In Stock	In Stock
50 mg	$672	In Stock	In Stock
100 mg	$936	In Stock	In Stock
200 mg	$1,260	-	In Stock
1 mL x 10 mM (in DMSO)	$191	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.05%

Appearance:solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

BAY-545 AI Summary

BAY-545 has demonstrated bioactivity as an antagonist at various adenosine receptors, with specific IC50 values reported for human A2B, A1, and A2A receptors in different cellular contexts. It exhibits selectivity towards certain adenosine receptors based on the IC50 value ratios. The compound also shows anti-inflammatory activity in human LL29 cells and PXR activation in human HepG2 cells. Pharmacokinetic properties include oral bioavailability, clearance, volume of distribution, half-life, and plasma clearance across species such as mice, rats, and dogs. Additionally, BAY-545 affects cell viability variably across different cell types, showing mixed impacts in HEK293T and human fibroblasts, and generally positive effects in U2OS cells. It also influences the thermal stability of various protein domains, with some showing minor increases and one domain a significant decrease, indicating potential interactions that may affect protein structural integrity and function..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	BAY-545 is an antagonist of A2B adenosine receptor(IC50 : 59 nM).
Targets&IC50	A2B receptor:59 nM

Chemical Properties

Molecular Weight	433.45
Formula	C₁₈H₂₂F₃N₃O₄S
Cas No.	1699717-32-2
Smiles	CCn1c(=O)n(CCC(F)(F)F)c2sc(C(=O)N3CCC(O)CC3)c(C)c2c1=O
Relative Density.	1.410 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 145 mg/mL (334.53 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (9.23 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3071 mL	11.5354 mL	23.0707 mL	115.3536 mL
5 mM	0.4614 mL	2.3071 mL	4.6141 mL	23.0707 mL
10 mM	0.2307 mL	1.1535 mL	2.3071 mL	11.5354 mL
20 mM	0.1154 mL	0.5768 mL	1.1535 mL	5.7677 mL
50 mM	0.0461 mL	0.2307 mL	0.4614 mL	2.3071 mL
100 mM	0.0231 mL	0.1154 mL	0.2307 mL	1.1535 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc