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(2R)-Octyl-α-hydroxyglutarate

Name: (2R)-Octyl-α-hydroxyglutarate
Brand: TargetMol
SKU: T19611
Rating: 4.5 (1 reviews)

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Catalog No. T19611Cas No. 1391194-67-4

Alias (2R)-Octyl-2-HG

(2R)-Octyl-α-hydroxyglutarate ((2R)-Octyl-2-HG) is a modified form of D-isomer 2-hydroxyglutarate.

(2R)-Octyl-α-hydroxyglutarate

😃Good

Catalog No. T19611Alias (2R)-Octyl-2-HGCas No. 1391194-67-4

(2R)-Octyl-α-hydroxyglutarate ((2R)-Octyl-2-HG) is a modified form of D-isomer 2-hydroxyglutarate.

Pack Size	Price	Availability	Quantity
2 mg	$95	5 days
1 mL x 10 mM (in DMSO)	$133	5 days

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Product Introduction

Bioactivity

Description	(2R)-Octyl-α-hydroxyglutarate ((2R)-Octyl-2-HG) is a modified form of D-isomer 2-hydroxyglutarate.
In vitro	Treatment of IDH1-WT HeLa cells with (2R)-octyl-α-hydroxyglutaric acid (a modified form of 2-hydroxyglutaric acid with high cellular uptake) results in a dose-dependent increase in DSB in log phase cells and has been used to examine the contribution of D-2-hydroxyglutarate to the oxidative mitochondrial process of IDH1 mutant cancer cells.
Synonyms	(2R)-Octyl-2-HG

Chemical Properties

Molecular Weight	260.33
Formula	C₁₃H₂₄O₅
Cas No.	1391194-67-4
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (384.13 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8413 mL	19.2064 mL	38.4128 mL	192.0639 mL
5 mM	0.7683 mL	3.8413 mL	7.6826 mL	38.4128 mL
10 mM	0.3841 mL	1.9206 mL	3.8413 mL	19.2064 mL
20 mM	0.1921 mL	0.9603 mL	1.9206 mL	9.6032 mL
50 mM	0.0768 mL	0.3841 mL	0.7683 mL	3.8413 mL
100 mM	0.0384 mL	0.1921 mL	0.3841 mL	1.9206 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc