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Inavolisib

Name: Inavolisib
Brand: TargetMol
SKU: T15375
Price: 80 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15375Cas No. 2060571-02-8

Alias RG6114, GDC-0077

Inavolisib (GDC-0077) is an orally available selective PI3Kα inhibitor with an IC50 value of 0.038 nM.It exerts its activity by binding to the ATP-binding site of PI3K, thereby inhibiting the phosphorylation of PIP2 to PIP3.

Inavolisib

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Purity: 99.90%

Catalog No. T15375Alias RG6114, GDC-0077Cas No. 2060571-02-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$80	In Stock	In Stock
5 mg	$223	In Stock	In Stock
10 mg	$392	In Stock	In Stock
25 mg	$668	In Stock	In Stock
50 mg	$1,090	In Stock	In Stock
100 mg	$1,780	In Stock	In Stock
200 mg	$2,380	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$425	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.90%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Inavolisib (GDC-0077) is an orally available selective PI3Kα inhibitor with an IC50 value of 0.038 nM.It exerts its activity by binding to the ATP-binding site of PI3K, thereby inhibiting the phosphorylation of PIP2 to PIP3.
Targets&IC50	MCF-7 cells:30 nM, HCC1954 cells:60 nM, PI3Kα:0.038 nM
In vitro	METHODS: Cell viability was assayed using Inavolisib (GDC-00777) up to 100 μmol/L in a panel of cancer cell lines. RESULTS Inavolisib (GDC-00777) is a stronger cellular antiproliferative inducer. [1]
In vivo	METHODS: p110a protein depletion was studied in a p110a mutant xenograft breast cancer model using Inavolisib (GDC-0077) at a single oral dose of 50 mg/kgDC-0077. RESULTS Inavolisib (GDC-0077) depleted p110a protein expression for up to 8 hours. [1]
Synonyms	RG6114, GDC-0077

Chemical Properties

Molecular Weight	407.37
Formula	C₁₈H₁₉F₂N₅O₄
Cas No.	2060571-02-8
Smiles	C[C@H](Nc1ccc2-c3nc(cn3CCOc2c1)N1[C@@H](COC1=O)C(F)F)C(N)=O
Relative Density.	1.63 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 240 mg/mL (589.15 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 10 mg/mL (24.55 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4548 mL	12.2739 mL	24.5477 mL	122.7385 mL
5 mM	0.4910 mL	2.4548 mL	4.9095 mL	24.5477 mL
10 mM	0.2455 mL	1.2274 mL	2.4548 mL	12.2739 mL
20 mM	0.1227 mL	0.6137 mL	1.2274 mL	6.1369 mL
50 mM	0.0491 mL	0.2455 mL	0.4910 mL	2.4548 mL
100 mM	0.0245 mL	0.1227 mL	0.2455 mL	1.2274 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc