Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SPEN-IN-1 (compound X1) is a selective inhibitor of the SPEN protein factor, exhibiting a dissociation constant (K d) of 47 nM. Notably, it exhibits high specificity for RepA, a 431-nucleotide domain within Xist (a non-coding RNA prototype), characterized by 8.5 repeats of a GC-rich motif instrumental in gene silencing [1].
Pack Size | Availability | Price/USD | Quantity |
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2 mg | 5 days | $ 278.00 |
Description | SPEN-IN-1 (compound X1) is a selective inhibitor of the SPEN protein factor, exhibiting a dissociation constant (K d) of 47 nM. Notably, it exhibits high specificity for RepA, a 431-nucleotide domain within Xist (a non-coding RNA prototype), characterized by 8.5 repeats of a GC-rich motif instrumental in gene silencing [1]. |
In vitro | SPEN-IN-1 (0-100 μM) inhibits RepA-PRC2 and RepA-SPEN with IC50 values of 30 and 48 μM, respectively [1]. It also inhibits RepA, PRC2, and SPEN with Kd values of 400, 47, and 420 nM, respectively [1]. Additionally, SPEN-IN-1 selectively disrupts the interaction between Xist and its homologous proteins both in vitro and in cells [1]. Notably, SPEN-IN-1 markedly suppresses the accumulation of H3K27me3 and PRC2 [1]. |
In vivo | SPEN-IN-1 reduces the in vivo interaction of RepA-SPEN [1]. |
Molecular Weight | 416.47 |
Formula | C27H20N4O |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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SPEN inhibitor 1 Others inhibitor inhibit