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GNE-0439

Name: GNE-0439
Brand: TargetMol
SKU: T11437
Price: 165 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11437Cas No. 1241902-40-8

Alias GNE0439, GNE 0439

GNE-0439 is a novel, Nav1.7-selective inhibitor with an IC50 of 0.34 uM that also inhibits Nav1.5 (IC50=38.3 uM) and mutant N1742K channels (IC50=0.37 uM), possessing a carboxylic acid group that binds outside the channel pore, distinguishing it from known selective VSD4 binders and making it a valuable tool for ion channel research.

GNE-0439

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Purity: 99.60%

Catalog No. T11437Alias GNE0439, GNE 0439Cas No. 1241902-40-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$165	-	In Stock
5 mg	$413	-	In Stock
10 mg	$689	-	In Stock
25 mg	$1,450	-	In Stock
50 mg	$1,980	-	In Stock
100 mg	$2,500	-	In Stock
1 mL x 10 mM (in DMSO)	$455	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.60%

ee:98.86%

Resource Download

COA CSFC ORP LCMS HNMR

Product Introduction

Bioactivity

Description	GNE-0439 is a novel, Nav1.7-selective inhibitor with an IC50 of 0.34 uM that also inhibits Nav1.5 (IC50=38.3 uM) and mutant N1742K channels (IC50=0.37 uM), possessing a carboxylic acid group that binds outside the channel pore, distinguishing it from known selective VSD4 binders and making it a valuable tool for ion channel research.
Targets&IC50	Nav1.7:0.34 uM
Synonyms	GNE0439, GNE 0439

Chemical Properties

Molecular Weight	345.48
Formula	C₂₁H₃₁NO₃
Cas No.	1241902-40-8
Smiles	C(N[C@@H]([C@@H](C)C)C(O)=O)(=O)C1=CC=C(C=C1)C2CCC(CCC)CC2
Relative Density.	1.058 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 105 mg/mL (303.92 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 4 mg/mL (11.58 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8945 mL	14.4726 mL	28.9452 mL	144.7262 mL
5 mM	0.5789 mL	2.8945 mL	5.7890 mL	28.9452 mL
10 mM	0.2895 mL	1.4473 mL	2.8945 mL	14.4726 mL
20 mM	0.1447 mL	0.7236 mL	1.4473 mL	7.2363 mL
50 mM	0.0579 mL	0.2895 mL	0.5789 mL	2.8945 mL
100 mM	0.0289 mL	0.1447 mL	0.2895 mL	1.4473 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc