TROP-2 Protein, Human, Recombinant (hFc)

Catalog No. TMPY-06972 Copy Product Info

TROP-2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 54.6 kDa and the accession number is NP_002344.2.

TROP-2 Protein, Human, Recombinant (hFc)

Catalog No. TMPY-06972

Copy Product Info

TROP-2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 54.6 kDa and the accession number is NP_002344.2.

Pack Size	Price	USA Stock	Global Stock
5 μg	$45	7-10 days	7-10 days
10 μg	$70	7-10 days	7-10 days
20 μg	$109	7-10 days	7-10 days
50 μg	$213	7-10 days	7-10 days
100 μg	$357	-	In Stock
200 μg	$625	7-10 days	7-10 days
500 μg	$1,290	7-10 days	7-10 days
1 mg	$2,330	7-10 days	7-10 days

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For In stock only · Estimated delivery:USA Stock (1-2 days) Global Stock (5-7 days)

For research use only—not for human use. No sales to individuals. Use as intended only.

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Biological Activity	Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	TROP-2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 54.6 kDa and the accession number is NP_002344.2.
Species	Human
Expression System	HEK293 Cells
Tag	C-hFc
Accession Number	NP_002344.2
Synonyms	tumor-associated calcium signal transducer 2,TROP-2,TROP2,TACD2,M1S1,GP50,GA733-1,GA7331,EGP-1,EGP1
Construction	A DNA sequence encoding the Human TACSTD2 (NP_002344.2) (Met1-Thr274) was expressed with the Fc region of human IgG1 at the C-terminus. Predicted N terminal: His 27
Protein Purity	≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.
Molecular Weight	54.6 kDa (predicted); 67 kDa (reducing conditions)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstituted with sterile deionized water to 1.18 mg/mL. Reconstitution conditions may vary depending on the lot.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Research Background	TROP-2, also referred to as tumor-associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1, is a cell surface glycoprotein highly expressed in a wide variety of epithelial cancers. In contrast, there is little or no expression of Trop-2 in adult somatic tissue. Because it is a cell surface protein that is selectively expressed in tumor cells, Trop-2 is a potential therapeutic target. The cytoplasmic tail of Trop-2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl-inositol binding consensus sequence. Trop-2 transduces an intracellular calcium signal, which are consistent with the hypothesis that it acts as a cell surface receptor and support a search for a physiological ligand. TROP2 encoding by an intronless gene was originally defined by the monoclonal antibody GA733, and is a member of a family of at least two type I membrane proteins. The other known member is GA733-2, also called EpCAM and TROP1. It has been suggested by studies that the GA733-1 gene was formed by the retroposition of the GA733-2 gene via an mRNA intermediate.