Shopping Cart

Your shopping cart is currently empty

PNU-96391

Name: PNU-96391
Brand: TargetMol
SKU: T28435
Price: 70 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T28435Cas No. 146798-66-5

Alias PNU96391, PNU 96391, OSU-6162, OSU6162, OSU 6162

PNU-96391 (OSU-6162) is an antagonist of dopamine D2 and a partial agonist of 5-HT2A. PNU-96391 can be used in research on the treatment of chronic diseases.

PNU-96391

Copy Product Info

😃Good

Purity: 99.53%

Catalog No. T28435Alias PNU96391, PNU 96391, OSU-6162, OSU6162, OSU 6162Cas No. 146798-66-5

PNU-96391 (OSU-6162) is an antagonist of dopamine D2 and a partial agonist of 5-HT2A. PNU-96391 can be used in research on the treatment of chronic diseases.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$70	-	In Stock
5 mg	$157	-	In Stock
10 mg	$233	-	In Stock
25 mg	$355	-	In Stock
50 mg	$497	-	In Stock
100 mg	$666	-	In Stock
200 mg	$888	-	In Stock
1 mL x 10 mM (in DMSO)	$148	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.53%

Appearance:Viscous

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

PNU-96391 AI Summary

PNU-96391 demonstrates bioactivity across multiple neurotransmitter systems and behaviors in rat models. It has affinity for dopamine D2 receptors (with Ki values of 3884.0 nM at low affinity and 755.0 nM at high affinity) and dopamine D3 receptors, while showing no activity at dopamine D2L receptors. It affects both limbic and striatal regions, influencing DOPA and DOPAC levels and reducing 5-HIAA levels. This compound alters extracellular dopamine levels and 5-hydroxytryptamine 1A receptor activity, impacting dopamine release and locomotor behavior. Subcutaneously administered at a dose of 100 umol/kg, it reduces spontaneous locomotor activity by 215%, decreases 5-HIAA levels, and increases DOPAC levels in the striatum. Additionally, it attenuates amphetamine-induced locomotor activity by 37%. Pharmacokinetic data indicate moderate to high clearance in rat, monkey, and dog models, suggesting efficient elimination and varying tissue distribution. PNU-96391 also exhibits antiviral activity against SARS-CoV-2, with an IC50 greater than 20000.0 nM in VERO-6 cell assays. These bioactivity profiles suggest potential for further exploration as a drug candidate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	PNU-96391 (OSU-6162) is an antagonist of dopamine D2 and a partial agonist of 5-HT2A. PNU-96391 can be used in research on the treatment of chronic diseases.
Synonyms	PNU96391, PNU 96391, OSU-6162, OSU6162, OSU 6162

Chemical Properties

Molecular Weight	281.41
Formula	C₁₅H₂₃NO₂S
Cas No.	146798-66-5
Smiles	S(C)(=O)(=O)C=1C=C(C=CC1)[C@H]2CN(CCC)CCC2
Relative Density.	1.093g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (195.44 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5535 mL	17.7677 mL	35.5353 mL	177.6767 mL
5 mM	0.7107 mL	3.5535 mL	7.1071 mL	35.5353 mL
10 mM	0.3554 mL	1.7768 mL	3.5535 mL	17.7677 mL
20 mM	0.1777 mL	0.8884 mL	1.7768 mL	8.8838 mL
50 mM	0.0711 mL	0.3554 mL	0.7107 mL	3.5535 mL
100 mM	0.0355 mL	0.1777 mL	0.3554 mL	1.7768 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc