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Anti-TARDBP Antibody (1H482)
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Catalog No. TMAB-13382
Anti-TARDBP Antibody (1H482) is a Rabbit antibody targeting TARDBP. Anti-TARDBP Antibody (1H482) can be used in WB,IHC-P,IF,ICC/IF,FCM,IHC-Fr.
Anti-TARDBP Antibody (1H482)
Anti-TARDBP Antibody (1H482)
😃Good
Catalog No. TMAB-13382
Anti-TARDBP Antibody (1H482) is a Rabbit antibody targeting TARDBP. Anti-TARDBP Antibody (1H482) can be used in WB,IHC-P,IF,ICC/IF,FCM,IHC-Fr.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $150 | 7-10 days | 7-10 days | |
| 50 μL | $263 | 7-10 days | 7-10 days | |
| 100 μL | $472 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-TARDBP Antibody (1H482) is a Rabbit antibody targeting TARDBP. Anti-TARDBP Antibody (1H482) can be used in WB,IHC-P,IF,ICC/IF,FCM,IHC-Fr. |
| Ig Type | IgG |
| Clone | 1H482 |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | WB: 1:1000-5000; IHC-P: 1:100-500; IF: 1:100-500; ICC/IF: 1:100-500; FCM: 1μg/Test; IHC-Fr: 1:100-500 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. In patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis, it is absent from the nucleus of affected neurons but it is the primary component of cytoplasmic ubiquitin-positive inclusion bodies. |
| Tissue Specificity | Ubiquitously expressed. In particular, expression is high in pancreas, placenta, lung, genital tract and spleen. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | PBS, Glycerol, BSA. |
| Concentration | 1mg/ml |
| Research Background | HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008] |
| Immunogen | A synthesized peptide: human TDP43 |
| Antigen Species | Human |
| Gene Name | TARDBP |
| Gene ID | |
| Protein Name | TAR DNA-binding protein 43 |
| Uniprot ID | |
| Function | DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR. |
| Molecular Weight | Theoretical: 45 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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