GDF-15 Protein, Human, Recombinant (hFc) V2

Catalog No. TMPY-01073U

GDF-15 Protein, Human, Recombinant (hFc) V2 is expressed in HEK293 Cells. The accession number is Q99988.

GDF-15 Protein, Human, Recombinant (hFc) V2

Catalog No. TMPY-01073U

GDF-15 Protein, Human, Recombinant (hFc) V2 is expressed in HEK293 Cells. The accession number is Q99988.

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Product Information

Biological Activity	Immobilized Human GFRAL, His Tag at 0.5 μg/ml (100 μl/well) on the plate. Dose response curve for Human GDF15, hFc Tag with the EC50 of 2.5 ng/ml determined by ELISA.
Description	GDF-15 Protein, Human, Recombinant (hFc) V2 is expressed in HEK293 Cells. The accession number is Q99988.
Species	Human
Expression System	HEK293 Cells
Accession Number	Q99988
Synonyms	PTGFB,PLAB,PDF,NAG-1,MIC-1,MIC1,growth differentiation factor 15,GDF-15
Construction	Ala197-Ile308
Protein Purity	> 95% as determined by Tris-Bis PAGE; > 92% as determined by HPLC
Molecular Weight	37.9 kDa (Predicted); 40-50 kDa (Due to glycosylation)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
Research Background	Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance.