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Anti-DNMT1 Polyclonal Antibody
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Catalog No. TMAB-00561
Alias MCMT, M.HsaI, EC 2.1.1.37, DNMT, DNA MTase HsaI, DNA methyltransferase HsaI, DNA (cytosine-5)-methyltransferase 1, CXXC-type zinc finger protein 9, CXXC9, AIM
Anti-DNMT1 Polyclonal Antibody is a Rabbit antibody targeting DNMT1. Anti-DNMT1 Polyclonal Antibody can be used in WB.
Anti-DNMT1 Polyclonal Antibody
Anti-DNMT1 Polyclonal Antibody
😃Good
Catalog No. TMAB-00561Alias MCMT, M.HsaI, EC 2.1.1.37, DNMT, DNA MTase HsaI, DNA methyltransferase HsaI, DNA (cytosine-5)-methyltransferase 1, CXXC-type zinc finger protein 9, CXXC9, AIM
Anti-DNMT1 Polyclonal Antibody is a Rabbit antibody targeting DNMT1. Anti-DNMT1 Polyclonal Antibody can be used in WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $222 | 7-10 days | |
| 100 μL | $374 | 7-10 days | |
| 200 μL | $528 | 7-10 days |
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-DNMT1 Polyclonal Antibody is a Rabbit antibody targeting DNMT1. Anti-DNMT1 Polyclonal Antibody can be used in WB. |
| Synonyms | MCMT, M.HsaI, EC 2.1.1.37, DNMT, DNA MTase HsaI, DNA methyltransferase HsaI, DNA (cytosine-5)-methyltransferase 1, CXXC-type zinc finger protein 9, CXXC9, AIM |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat (predicted:Chicken,Dog,Pig,Cow,Horse,Sheep) |
| Verified Activity | Sample: Bone (Mouse) Lysate at 40 μg LympHnode (Rat) Lysate at 40 μg Primary: Anti-Dnmt1 (TMAB-00561) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 178 kDa Observed band size: 144 kDa |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. |
| Tissue Specificity | Ubiquitous; highly expressed in fetal tissues, heart, kidney, placenta, peripheral blood mononuclear cells, and expressed at lower levels in spleen, lung, brain, small intestine, colon, liver, and skeletal muscle. Isoform 2 is less expressed than isoform |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]. |
| Immunogen | KLH conjugated synthetic peptide: human Dnmt1 |
| Antigen Species | Human |
| Gene Name | DNMT1 |
| Gene ID | |
| Protein Name | DNA(cytosine-5)-methyltransferase 1 |
| Uniprot ID | |
| Biology Area | DNMTs |
| Function | Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. |
| Molecular Weight | Theoretical: 178 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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