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Mal-Exatecan

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Catalog No. T205546Cas No. 3028213-52-4
Alias Mal-DX-8951, Mal-DX8951

Mal-Exatecan (Mal-DX-8951) is a malonamide (Mal)-modified antibody-drug conjugate used for preparing ADCs (antibody-drug conjugates) and studying cancer. Exatecan is an effective topoisomerase I inhibitor

Mal-Exatecan

Mal-Exatecan

😃Good
Purity: 99.39%
Catalog No. T205546Alias Mal-DX-8951, Mal-DX8951Cas No. 3028213-52-4
Mal-Exatecan (Mal-DX-8951) is a malonamide (Mal)-modified antibody-drug conjugate used for preparing ADCs (antibody-drug conjugates) and studying cancer. Exatecan is an effective topoisomerase I inhibitor
Pack SizePriceAvailabilityQuantity
1 mg$153In Stock
5 mgPreferential7-10 days
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Purity:99.39%
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Product Introduction

Bioactivity
Description
Mal-Exatecan (Mal-DX-8951) is a malonamide (Mal)-modified antibody-drug conjugate used for preparing ADCs (antibody-drug conjugates) and studying cancer. Exatecan is an effective topoisomerase I inhibitor
AliasMal-DX-8951, Mal-DX8951
Chemical Properties
Molecular Weight628.65
FormulaC34H33FN4O7
Cas No.3028213-52-4
SmilesN(C(CCCCCN1C(=O)C=CC1=O)=O)[C@@H]2C3=C4C(C=5N(C4)C(=O)C6=C(C5)[C@](CC)(O)C(=O)OC6)=NC=7C3=C(CC2)C(C)=C(F)C7
Storage & Solubility Information
Storagekeep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (127.26 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.5907 mL7.9536 mL15.9071 mL79.5355 mL
5 mM0.3181 mL1.5907 mL3.1814 mL15.9071 mL
10 mM0.1591 mL0.7954 mL1.5907 mL7.9536 mL
20 mM0.0795 mL0.3977 mL0.7954 mL3.9768 mL
50 mM0.0318 mL0.1591 mL0.3181 mL1.5907 mL
100 mM0.0159 mL0.0795 mL0.1591 mL0.7954 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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