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RNF5 inhibitor inh-02

Name: RNF5 inhibitor inh-02
Brand: TargetMol
SKU: T35883
Price: 78 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T35883Cas No. 324579-65-9

RNF5 inhibitor inh-02 is a selective inhibitor of the ubiquitin ligase RNF5/RMA1, which can significantly rescue F508del-CFTR (cystic fibrosis transmembrane conductance regulator with a deletion at position 508 of phenylalanine) and regulate ATG4B and paxillin, making it useful for studying cystic fibrosis (CF).

RNF5 inhibitor inh-02

🥰Excellent

Purity: 99.23%

Catalog No. T35883Cas No. 324579-65-9

Pack Size	Price	Availability
1 mg	$78	In Stock
5 mg	$189	In Stock
10 mg	$328	In Stock
25 mg	$689	In Stock
50 mg	$1,180	In Stock
100 mg	$1,980	In Stock
200 mg	$2,680	In Stock
1 mL x 10 mM (in DMSO)	$198	In Stock

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Batch Information

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Purity:99.23%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	384.5
Formula	C₂₃H₂₀N₄S
Cas No.	324579-65-9
Smiles	N=1SC(=NC(=NC=2C=CC=CC2)C=3C=CC=CC3)N(C1C)CC=4C=CC=CC4
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (208.06 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6008 mL	13.0039 mL	26.0078 mL	130.0390 mL
5 mM	0.5202 mL	2.6008 mL	5.2016 mL	26.0078 mL
10 mM	0.2601 mL	1.3004 mL	2.6008 mL	13.0039 mL
20 mM	0.1300 mL	0.6502 mL	1.3004 mL	6.5020 mL
50 mM	0.0520 mL	0.2601 mL	0.5202 mL	2.6008 mL
100 mM	0.0260 mL	0.1300 mL	0.2601 mL	1.3004 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc