Shopping Cart
Remove All
Your shopping cart is currently empty
Eliprodil
Copy Product Info
😃Good
Catalog No. T1751Cas No. 119431-25-3
Alias SL-820715
Eliprodil (SL-820715)(SL-820715), a non-competitive NR2B-NMDA receptor antagonist(IC50: 1 uM), less effective for NR2A- and NR2C-containing receptors(IC50> 100 uM). It has been used in trials studying the treatment of Parkinson Disease and Movement Disorders.
Eliprodil
Copy Product Info😃Good
Purity: 99.77%
Catalog No. T1751Alias SL-820715Cas No. 119431-25-3
Eliprodil (SL-820715)(SL-820715), a non-competitive NR2B-NMDA receptor antagonist(IC50: 1 uM), less effective for NR2A- and NR2C-containing receptors(IC50> 100 uM). It has been used in trials studying the treatment of Parkinson Disease and Movement Disorders.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | $33 | In Stock | In Stock | |
| 25 mg | $64 | In Stock | In Stock | |
| 50 mg | $119 | In Stock | In Stock | |
| 100 mg | $178 | - | In Stock | |
| 500 mg | $427 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock | In Stock |
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
Select Batch
Purity:99.77%
Color:White
Contact us for more batch information
Product Introduction
Eliprodil AI Summary
Eliprodil exhibits a range of bioactivities across different biological pathways and receptors. It demonstrates potent competitive antagonist activity at the GluN2B subunit of the NMDA receptor, with a high affinity indicated by a Ki value of 13.0 nM, effectively displacing [3H]ifenprodil. It also shows inhibitory activity against the NMDA responses at NR1A/2B receptors with an IC50 of 1400.0 nM, and exhibits affinity for the alpha-1 adrenergic receptor with an IC50 of 3300.0 nM. In addition, it inhibits voltage-gated K+ currents by 67.0% at 10 µM concentration and has an ED50 of 1.0 mg/kg in the mouse electric shock assay. Additionally, it shows neuroprotective effects in a rat model of focal cerebral ischemia by reducing infarct volume when administered intravenously at 1 mg/kg. Eliprodil also displays antiplasmodial activity against Plasmodium falciparum with IC50 values ranging from 251.19 nM to 2511.89 nM. Furthermore, it shows potential antiviral activity against SARS-CoV-2, inhibiting virus-induced cytotoxicity of VERO-6 cells, although with IC50 values greater than 20000.0 nM. Its diverse range of bioactivities, including modulation of glutamatergic neurotransmission and potential pharmacological effects on various receptors, suggests its importance in therapeutic applications..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Eliprodil (SL-820715)(SL-820715), a non-competitive NR2B-NMDA receptor antagonist(IC50: 1 uM), less effective for NR2A- and NR2C-containing receptors(IC50> 100 uM). It has been used in trials studying the treatment of Parkinson Disease and Movement Disorders. |
| Targets&IC50 | NR2B-NMDA:1 μM |
| Synonyms | SL-820715 |
| Molecular Weight | 347.85 |
| Formula | C20H23ClFNO |
| Cas No. | 119431-25-3 |
| Smiles | OC(CN1CCC(Cc2ccc(F)cc2)CC1)c1ccc(Cl)cc1 |
| Relative Density. | 1.205 g/cm3 |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 6 mg/mL (17.25 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
| |||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy Eliprodil | purchase Eliprodil | Eliprodil cost | order Eliprodil | Eliprodil chemical structure | Eliprodil formula | Eliprodil molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.