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ZK824190

🥰Excellent
Catalog No. T13408Cas No. 2254001-81-3

ZK824190 is an orally available and selective inhibitor of urokinase plasminogen activator (uPA), with IC50 values of 237 nM for uPA, 1600 nM for tPA, and 1850 nM for Plasmin.

ZK824190
Other Forms of ZK824190:
ZK824190 hydrochlorideT627312629177-12-2
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ZK824190

🥰Excellent
Purity: 98.84%
Catalog No. T13408Cas No. 2254001-81-3
ZK824190 is an orally available and selective inhibitor of urokinase plasminogen activator (uPA), with IC50 values of 237 nM for uPA, 1600 nM for tPA, and 1850 nM for Plasmin.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$272In StockIn Stock
5 mg$569In StockIn Stock
10 mg$816In StockIn Stock
25 mg$1,250In StockIn Stock
50 mg$1,680In StockIn Stock
100 mg$2,270In StockIn Stock
1 mL x 10 mM (in DMSO)$589In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:98.84%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
ZK824190 is an orally available and selective inhibitor of urokinase plasminogen activator (uPA), with IC50 values of 237 nM for uPA, 1600 nM for tPA, and 1850 nM for Plasmin.
Targets&IC50
TPA:1600 nM , Plasmin:1850 nM , uPA:237 nM
In vivo
In rats with experimental autoimmune encephalomyelitis (EAE) model, ZK824190 (2?mg/kg; p.o.) exhibited a relatively high oral availability(F?=?55%; Cmax=?0.64?g/mL and AUC?=?2.2?h*g/mL) and a moderate half time of 2.8 h[1].
Chemical Properties
Molecular Weight414.4
FormulaC22H20F2N2O4
Cas No.2254001-81-3
SmilesO(C=1C=C(C=CC1)C2=CC(CN)=CC=C2)C=3N=C(O[C@@H](C(O)=O)CC)C(F)=CC3F
Relative Density.no data available
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 12 mg/ml (28.96 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.83 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4131 mL12.0656 mL24.1313 mL120.6564 mL
5 mM0.4826 mL2.4131 mL4.8263 mL24.1313 mL
10 mM0.2413 mL1.2066 mL2.4131 mL12.0656 mL
20 mM0.1207 mL0.6033 mL1.2066 mL6.0328 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

ZK-824190ZK824190ZK 824190UrokinaseuPAtPAThreonine proteasesSerineProteaseSerine proteasesSerine ProteaseSerine endopeptidasesSerineSer/Thr ProteaseproteasePlasminogen activator inhibitor-1plasminogenPlasminPAI-1multiple sclerosisInhibitorinhibit
Related Tags: buy ZK824190 | purchase ZK824190 | ZK824190 cost | order ZK824190 | ZK824190 chemical structure | ZK824190 in vivo | ZK824190 formula | ZK824190 molecular weight
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