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FLT1 Protein, Human, Recombinant (hFc)

Catalog No. TMPY-00119
Synonyms: VEGFR1, VEGFR-1, fms-related tyrosine kinase 1, FLT-1, FLT

FLT1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.1 kDa and the accession number is P17948-4.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
FLT1 Protein, Human, Recombinant (hFc)
Pack Size Availability Price/USD Quantity
50 μg 5 days $ 398.00
500 μg 5 days $ 2,580.00
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Biological Description
Technical Params
Product Properties
References and Literature
Description FLT1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.1 kDa and the accession number is P17948-4.
Species Human
Expression System HEK293 Cells
Tag C-hFc
Accession Number P17948-4
Synonyms VEGFR1, VEGFR-1, fms-related tyrosine kinase 1, FLT-1, FLT
Construction The Human FLT1 (NP_001153503.1) (Met1-Ile328) was expressed with the Fc region of Human IgG1 at the C-terminus.
Protein Purity > 95 % as determined by SDS-PAGE.
Molecular Weight 61.1 kDa (predicted)
Endotoxin < 1.0 EU/μg of the protein as determined by the LAL method.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice.

Research Background Vascular endothelial growth factor receptor 1, also known as VEGFR-1, Fms-like tyrosine kinase 1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor FLT, Vascular permeability factor receptor and FLT1, is a single-pass type I membrane protein and secreted protein which belongs to theprotein kinase superfamily, Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR-1 / FLT1 contains sevenIg-like C2-type (immunoglobulin-like) domains and oneprotein kinase domain. VEGFR-1 / FLT1 is expressed mostly in normal lung, but also in placenta, liver, kidney, heart and brain tissues. It is specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. VEGFR-1 / FLT1 is not expressed in tumor cell lines. VEGFR-1 / FLT1 is an essential receptor tyrosine kinase that regulates mammalian vascular development and embryogenesis. EGF-induced angiogenesis requires inverse regulation of VEGFR-1 and VEGFR-2 in tumor-associated endothelial cells. VEGFR-1 / FLT1 is a receptor for VEGF, VEGFB and PGF. It has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

References and Literature

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Keywords

FLT1 Protein, Human, Recombinant (hFc) VEGFR1 VEGFR-1 FLT 1 VEGFR 1 FLT1 fms-related tyrosine kinase 1 FLT-1 FLT recombinant recombinant-proteins proteins protein

 

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