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Anti-RIZ1 Antibody (7G445)
😃Good
Catalog No. TMAY-01762
Alias RIZ2, RIZ1, RIZ, PR domain containing 2, with ZNF domain, MTB-ZF, KMT8, HUMHOXY1
Anti-RIZ1 Antibody (7G445) is a Mouse antibody targeting RIZ1. Anti-RIZ1 Antibody (7G445) can be used in ELISA.
Anti-RIZ1 Antibody (7G445)
Anti-RIZ1 Antibody (7G445)
😃Good
Catalog No. TMAY-01762Alias RIZ2, RIZ1, RIZ, PR domain containing 2, with ZNF domain, MTB-ZF, KMT8, HUMHOXY1
Anti-RIZ1 Antibody (7G445) is a Mouse antibody targeting RIZ1. Anti-RIZ1 Antibody (7G445) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-RIZ1 Antibody (7G445) is a Mouse antibody targeting RIZ1. Anti-RIZ1 Antibody (7G445) can be used in ELISA. |
| Alias | RIZ2, RIZ1, RIZ, PR domain containing 2, with ZNF domain, MTB-ZF, KMT8, HUMHOXY1 |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 7G445 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:1000-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human RIZ1 (rh RIZ1; TMPY-01265; NP_036363.2; Met1-Ala200). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | PR domain containing 2, with ZNF domain (PRDM2), also known as zinc finger protein RIZ, is a member of histone methyltransferase (HMT) class enzymes that methylate lysine residues of histones or proteins. HMTs contain a conserved catalytic core termed the SET domain, which shares sequence homology with an independently described sequence motif, the PR domain. PRDM2 contains 8 C2H2-type zinc fingers and a distinct SET domain, and is highly expressed in retinoblastoma cell lines and in brain tumors, as well as in a number of other cell lines and in brain, heart, skeletal muscle, liver and spleen. PRDM2 is an S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3, and is identified as a tumor suppressor. It is reported that intact PR( SET) sequence is required for tumor suppression functions, mutations in the PR domain caused activity reduction in human cancers. Also, S-adenosylhomocysteine or methyl donor deficiency inhibits RIZ1 and other H3 lysine 9 methylation activities. PRDM2 may also function as a DNA-binding transcription factor. It binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and acts as a transcriptional activator. Besides, PRDM2 (RIZ) can bind to the retinoblastoma protein (RB) and also Interacts with GATA3. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human RIZ1 Protein (TMPY-01265) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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