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Saikosaponin B2

Name: Saikosaponin B2
Brand: TargetMol
SKU: T3810
Price: 36 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3810Cas No. 58316-41-9

Saikosaponin B2 acts on HCV E2 and inhibits infection by several genotypic strains and prevents binding of serum-derived HCV onto hepatoma cells. Saikosaponin B2 (5 μM) induces differentiation of B16 melanoma cells, with potentiation of expressions of tyrosinase and melanogenesis.

Saikosaponin B2

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Purity: 99.59%

Catalog No. T3810Cas No. 58316-41-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$36	In Stock	In Stock
5 mg	$79	In Stock	In Stock
10 mg	$137	In Stock	In Stock
25 mg	$252	In Stock	In Stock
50 mg	$376	In Stock	In Stock
100 mg	$565	-	In Stock
500 mg	$1,230	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.59%

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Saikosaponin B2 AI Summary

Saikosaponin B2 demonstrates cytotoxicity against human HepG2 cells with an IC50 value of 35100.0 nM and exhibits antiviral activity against HCoV-229E in human MRC-5 cells with an EC50 of 1700.0 nM. It shows cytotoxicity against human MRC-5 cells with a CC50 of 383000.0 nM, yielding a selectivity ratio of 222.0 for CC50 to EC50 in MRC-5 cells. Additionally, it exhibits neuroprotective activity against H2O2-induced neuronal cell death in human SH-SY5Y cells, with varying levels of cell viability at different concentrations..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	780.98
Formula	C₄₂H₆₈O₁₃
Cas No.	58316-41-9
Smiles	[H][C@@]1(O[C@H]2[C@@H](O)[C@@H](C)O[C@@]([H])(O[C@H]3CC[C@@]4(C)[C@@]([H])(CC[C@]5(C)[C@]4([H])C=CC4=C6CC(C)(C)CC[C@]6(CO)[C@H](O)C[C@@]54C)[C@]3(C)CO)[C@@H]2O)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Relative Density.	1.35 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 245 mg/mL (313.71 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (2.56 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2804 mL	6.4022 mL	12.8044 mL	64.0221 mL
5 mM	0.2561 mL	1.2804 mL	2.5609 mL	12.8044 mL
10 mM	0.1280 mL	0.6402 mL	1.2804 mL	6.4022 mL
20 mM	0.0640 mL	0.3201 mL	0.6402 mL	3.2011 mL
50 mM	0.0256 mL	0.1280 mL	0.2561 mL	1.2804 mL
100 mM	0.0128 mL	0.0640 mL	0.1280 mL	0.6402 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc