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L-2-Hydroxyglutaric acid disodium
🥰Excellent
Catalog No. T13748Cas No. 63512-50-5
Alias (S)-2-Hydroxyglutaric acid disodium
L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium) is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity(Km and Ki of 2.52 mM and 11.13 mM, respectively).
L-2-Hydroxyglutaric acid disodium
🥰Excellent
Purity: 99.92%
Catalog No. T13748Alias (S)-2-Hydroxyglutaric acid disodiumCas No. 63512-50-5
L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium) is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity(Km and Ki of 2.52 mM and 11.13 mM, respectively).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $45 | In Stock | |
| 25 mg | $83 | In Stock | |
| 50 mg | $136 | In Stock | |
| 100 mg | $186 | In Stock |
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Purity:99.92%
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Product Introduction
Bioactivity
Chemical Properties
| Description | L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium) is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity(Km and Ki of 2.52 mM and 11.13 mM, respectively). |
| In vitro | L-2-hydroxyglutarate can effectively inhibit 2-oxoglutarate (2-OG) dependent dioxygenases (2OGDs), including eleven eleven translocation (TET) enzymes [2]. |
| Synonyms | (S)-2-Hydroxyglutaric acid disodium |
| Molecular Weight | 192.08 |
| Formula | C5H6Na2O5 |
| Cas No. | 63512-50-5 |
| Smiles | [Na+].[Na+].O[C@@H](CCC([O-])=O)C([O-])=O |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 100 mg/mL (520.62 mM), Sonication is recommended.  DMSO: < 1 mg/mL (insoluble or slightly soluble) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords
renalmodifierMitochondrialMetabolismMitochondrial MetabolismmethylationL-2-Hydroxyglutaric acid disodiumL2Hydroxyglutaric acid disodiumL-2-Hydroxyglutaric acidL 2 Hydroxyglutaric acid disodiumInhibitorinhibitHistoneDemethylaseHistone Demethylasehistoneepigeneticdemethylasescancer2-Hydroxyglutaric acid disodium2-Hydroxyglutaric acid
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