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BM635 mesylate (1493762-74-5 free base)
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Catalog No. T10563L2
Alias BM635 mesylate
BM635 mesylate is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv).
BM635 mesylate (1493762-74-5 free base)
😃Good
Catalog No. T10563L2Alias BM635 mesylate
BM635 mesylate is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,820 | 10-14 weeks | |
| 50 mg | $2,380 | 10-14 weeks | |
| 100 mg | $3,100 | 10-14 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | BM635 mesylate is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv). |
| Targets&IC50 | M. tuberculosis (strain H37Rv):（MIC50） 0.08 μM |
| In vivo | BM635 has potent MIC (0.12 μM), Tox50:MIC ratio of >100, and good microsomal stability in mice (1.4 mL/min/g). When tested in an acute murine infection model at multiple doses, BM635 exhibits potent anti-tubercular activity (ED99: 49 mg/Kg; IC95%: 43–54 mg/Kg) [1]. The half-life in vivo of BM635 is 1h, allowing a reasonable maximum concentration (Cmax: 1.62 μM) and a moderate bioavailability (46%) [2]. |
| Synonyms | BM635 mesylate |
| Molecular Weight | 488.61 |
| Formula | C26H33FN2O4S |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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