Powder: -20°C for 3 years | In solvent: -80°C for 1 year
RO0270608, the active metabolite of R411, is a dual α4β1/α4β7 integrin antagonist with anti-inflammatory activity[1][2].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 347.00 |
Description | RO0270608, the active metabolite of R411, is a dual α4β1/α4β7 integrin antagonist with anti-inflammatory activity[1][2]. |
In vitro | RO0270608 inhibits α4/β7 mediated cell adhesion with an IC50 of 33 nM. In a human T-cell VCAM/anti CD3 costimulation assay RO0270608 causes a pronounced inhibition of T-cell proliferation (IC50=30 nM)[2]. |
In vivo | In a murine ovalbumin (OVA) model of airway inflammation, RO0270608 administered intranasally (i.n.) eliminates the accumulation of allergen-induced inflammatory cells. |
Synonyms | RO0270608 |
Molecular Weight | 505.78 |
Formula | C24H19Cl3N2O4 |
CAS No. | 220846-33-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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RO0270608 220846-33-3 RO-0270608 RO 0270608 inhibitor inhibit