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Dalotuzumab
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Catalog No. T76800Cas No. 1005389-60-5
Alias MK-0646, h7C10
Dalotuzumab (MK-0646) is a recombinant humanized IgG1 monoclonal antibody that specifically targets the insulin-like growth factor 1 receptor (IGF-1R). its mechanism of action involves the inhibition of IGF-mediated oncogenic signaling, which subsequently induces apoptosis and cell cycle arrest in tumor cells, and it has demonstrated enhanced antitumor efficacy when used in combination with other chemotherapeutic agents.
Dalotuzumab
Dalotuzumab
😃Good
Catalog No. T76800Alias MK-0646, h7C10Cas No. 1005389-60-5
Dalotuzumab (MK-0646) is a recombinant humanized IgG1 monoclonal antibody that specifically targets the insulin-like growth factor 1 receptor (IGF-1R). its mechanism of action involves the inhibition of IGF-mediated oncogenic signaling, which subsequently induces apoptosis and cell cycle arrest in tumor cells, and it has demonstrated enhanced antitumor efficacy when used in combination with other chemotherapeutic agents.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $247 | - | In Stock | |
| 5 mg | $645 | - | In Stock | |
| 10 mg | $987 | - | In Stock | |
| 25 mg | $1,460 | - | In Stock | |
| 50 mg | $1,970 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:97.6% (SDS-PAGE); 99.3% (SEC-HPLC)
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| Description | Dalotuzumab (MK-0646) is a recombinant humanized IgG1 monoclonal antibody that specifically targets the insulin-like growth factor 1 receptor (IGF-1R). its mechanism of action involves the inhibition of IGF-mediated oncogenic signaling, which subsequently induces apoptosis and cell cycle arrest in tumor cells, and it has demonstrated enhanced antitumor efficacy when used in combination with other chemotherapeutic agents. |
| In vitro | Dalotuzumab (33 nM, 24 h) was used to treat IGF-1-induced MCF7 cells, and the changes in cell cycle and the expression of IGF-IR and IRS-1 proteins were detected. Results: Dalotuzumab was able to induce cell cycle arrest in IGF-1-induced MCF7 cells and also inhibited the autophosphorylation of IGF-IR and IRS-1. [1] |
| In vivo | Methods: Dalotuzumab (MK-0646) (250 µg/mouse initially, then 125 µg/mouse, intraperitoneally twice a week for 40 days) was used to treat Swiss nude mice bearing MCF-7 and A549 xenograft tumors, and its tumor inhibition was observed. Results: Dalotuzumab reduced the average tumor volume of nude mice in the MCF-7 and A549 models by 70% and 72%, respectively. [1] |
| Synonyms | MK-0646, h7C10 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | IGF1-R/IGFR1/CD221 |
| Molecular Weight | 146.36 kDa |
| Cas No. | 1005389-60-5 |
| Color | Transparent |
| Appearance | Liquid |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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