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Anti-TEM8 Polyclonal Antibody
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Catalog No. TMAB-13450
Anti-TEM8 Polyclonal Antibody is a Rabbit antibody targeting TEM8. Anti-TEM8 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
Anti-TEM8 Polyclonal Antibody
Anti-TEM8 Polyclonal Antibody
Copy Product Info😃Good
Catalog No. TMAB-13450
Anti-TEM8 Polyclonal Antibody is a Rabbit antibody targeting TEM8. Anti-TEM8 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Anti-TEM8 Polyclonal Antibody is a Rabbit antibody targeting TEM8. Anti-TEM8 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Human,Mouse (predicted:Rat,Rabbit) |
| Verified Activity | 1. Sample: HepG2 (Human) Cell Lysate at 30 μg k562 (human) Cell Lysate at 30 μg Primary: Anti-TEM8 (TMAB-13450) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 59 kD Observed band size: 62 kD 2. Paraformaldehyde-fixed, paraffin embedded (Human esophageal cancer); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (TEM8) Polyclonal Antibody, Unconjugated (TMAB-13450) at 1: 200 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructions and DAB staining. 3. Sample: Lane 1: Human A549 cell lysates Lane 2: Human HepG2 cell lysates Lane 3: Human SH-SY5Y cell lysates Lane 4: Human Hela cell lysates Lane 5: Human U2os cell lysates Primary: Anti-TEM8 (TMAB-13450) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 63 kD Observed band size: 61 kD 4. Sample: Siha (Human) Cell Lysate at 30 μg Uterus (Mouse) Lysate at 40 μg Primary: Anti-TEM8 (TMAB-13450) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 59 kD Observed band size: 62 kD |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cell membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane; Single-pass type I membrane protein. Cell projection, filopodium membrane; Single-pass type I membrane protein. Note=At the membrane of lamellipodia and at the tip of actin-enriched filopodia. Colocalizes with actin at the base of lamellipodia. |
| Tissue Specificity | Detected in umbilical vein endothelial cells (at protein level). Highly expressed in tumor endothelial cells. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008] |
| Immunogen | KLH conjugated synthetic peptide: human TEM8 |
| Antigen Species | Human |
| Gene Name | ANTXR1 |
| Gene ID | |
| Protein Name | Anthrax toxin receptor 1 |
| Uniprot ID | |
| Function | Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. |
| Molecular Weight | Theoretical: 63 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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