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NLX-204 hydrochloride(2170405-10-2 free base)

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Catalog No. T22379L

NLX-204 hydrochloride is a potent and selective ERK1/2 phosphorylation-preferring serotonin 5 HT1A receptor agonist(pKi = 10.19).

NLX-204 hydrochloride(2170405-10-2 free base)
Other Forms of NLX-204 hydrochloride(2170405-10-2 free base):
NLX-204T223792170405-10-2
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NLX-204 hydrochloride(2170405-10-2 free base)

🥰Excellent
Purity: 99.59%
Catalog No. T22379L
NLX-204 hydrochloride is a potent and selective ERK1/2 phosphorylation-preferring serotonin 5 HT1A receptor agonist(pKi = 10.19).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$54In StockIn Stock
5 mg$111In StockIn Stock
10 mg$159In StockIn Stock
25 mg$286In StockIn Stock
50 mg$397In StockIn Stock
100 mg$582In StockIn Stock
1 mL x 10 mM (in DMSO)$127In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:99.59%
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Product Introduction

Bioactivity
Description
NLX-204 hydrochloride is a potent and selective ERK1/2 phosphorylation-preferring serotonin 5 HT1A receptor agonist(pKi = 10.19).
In vivo
NLX-204, displayed high selectivity in the SafetyScreen44 panel (including hERG channel), high solubility, metabolic stability, and Caco-2 penetration and did not block CYP3A4, CYP2D6 isoenzymes, or P-glycoprotein.?Preliminary in vivo studies confirmed its promising pharmacokinetic profile.?NLX-204 also robustly stimulated ERK1/2 phosphorylation in rat cortex and showed highly potent (MED = 0.16 mg/kg) and efficacious antidepressant-like activity, totally eliminating immobility in the rat Porsolt test.
Chemical Properties
Molecular Weight446.32
FormulaC20H23Cl2F2N3O2
SmilesO=C(N1CCC(CNCCOC2=NC=CC=C2)(CC1)F)C3=CC=C(C(Cl)=C3)F.Cl
Relative Density.no data available
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 11 mg/mL (24.65 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2405 mL11.2027 mL22.4054 mL112.0272 mL
5 mM0.4481 mL2.2405 mL4.4811 mL22.4054 mL
10 mM0.2241 mL1.1203 mL2.2405 mL11.2027 mL
20 mM0.1120 mL0.5601 mL1.1203 mL5.6014 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

NLX204 hydrochloride(2170405102 free base)NLX-204 HydrochlorideNLX204 HydrochlorideNLX 204 hydrochloride(2170405 10 2 free base)NLX 204 Hydrochloride5HTReceptor5-HT1A5HT Receptor2170405-10-2 free base2170405-10-2
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