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NLX-204 hydrochloride(2170405-10-2 free base)

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Catalog No. T22379L

NLX-204 hydrochloride is a potent and selective ERK1/2 phosphorylation-preferring serotonin 5 HT1A receptor agonist(pKi = 10.19).

NLX-204 hydrochloride(2170405-10-2 free base)
Other Forms of NLX-204 hydrochloride(2170405-10-2 free base):
NLX-204T223792170405-10-2
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NLX-204 hydrochloride(2170405-10-2 free base)

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Purity: 99.59%
Catalog No. T22379L
NLX-204 hydrochloride is a potent and selective ERK1/2 phosphorylation-preferring serotonin 5 HT1A receptor agonist(pKi = 10.19).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$54In StockIn Stock
5 mg$111In StockIn Stock
10 mg$159In StockIn Stock
25 mg$286In StockIn Stock
50 mg$397In StockIn Stock
100 mg$582In StockIn Stock
1 mL x 10 mM (in DMSO)$127In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:99.59%
Appearance:Solid
Color:White
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
NLX-204 hydrochloride is a potent and selective ERK1/2 phosphorylation-preferring serotonin 5 HT1A receptor agonist(pKi = 10.19).
In vivo
NLX-204, displayed high selectivity in the SafetyScreen44 panel (including hERG channel), high solubility, metabolic stability, and Caco-2 penetration and did not block CYP3A4, CYP2D6 isoenzymes, or P-glycoprotein.?Preliminary in vivo studies confirmed its promising pharmacokinetic profile.?NLX-204 also robustly stimulated ERK1/2 phosphorylation in rat cortex and showed highly potent (MED = 0.16 mg/kg) and efficacious antidepressant-like activity, totally eliminating immobility in the rat Porsolt test.
Chemical Properties
Molecular Weight446.32
FormulaC20H23Cl2F2N3O2
SmilesO=C(N1CCC(CNCCOC2=NC=CC=C2)(CC1)F)C3=CC=C(C(Cl)=C3)F.Cl
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 11 mg/mL (24.65 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2405 mL11.2027 mL22.4054 mL112.0272 mL
5 mM0.4481 mL2.2405 mL4.4811 mL22.4054 mL
10 mM0.2241 mL1.1203 mL2.2405 mL11.2027 mL
20 mM0.1120 mL0.5601 mL1.1203 mL5.6014 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

NLX204 hydrochloride(2170405102 free base)NLX-204 HydrochlorideNLX204 HydrochlorideNLX 204 hydrochloride(2170405 10 2 free base)NLX 204 Hydrochloride5HTReceptor5-HT1A5HT Receptor2170405-10-2 free base2170405-10-2
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