Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Compound 8b hydrochloride, a selective S1R agonist, exhibits affinity with K i s of 1.1 nM for S1R and 88 nM for S2R. It demonstrates neuroprotective effects against ROS and NMDA-induced neurotoxicity [1].
Pack Size | Availability | Price/USD | Quantity |
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2 mg | 5 days | $ 97.00 |
Description | Compound 8b hydrochloride, a selective S1R agonist, exhibits affinity with K i s of 1.1 nM for S1R and 88 nM for S2R. It demonstrates neuroprotective effects against ROS and NMDA-induced neurotoxicity [1]. |
In vitro | S1R agonist 2 (Compound 8b; 0.1-5 μM) hydrochloride significantly enhances neurite outgrowth induced by nerve growth factor (NGF) in a dose-dependent manner [1]. At a concentration of 1 μM over 24 hours, S1R agonist 2 hydrochloride also markedly inhibits Rotenone-induced cellular damage in SHSY5Y cells [1]. Furthermore, this compound offers neuroprotection against NMDA stimulation in SHSY5Y cells when administered from 0.1 to 5 μM over 24 hours [1]. At varying concentrations (0-10 μM) and durations (24-72 h), S1R agonist 2 hydrochloride exhibits no cytotoxicity in A549, LoVo, and Panc-1 cells [1]. |
In vivo | Compound 8b (S1R agonist 2; 0.1-50 μM; 120 h) hydrochloride at a concentration of 10 μM does not induce embryonic mortality (100% survival of embryos), yet at the highest dosage (50 μM), it induces death in all embryos [1]. |
Molecular Weight | 345.91 |
Formula | C21H28ClNO |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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S1R agonist 2 hydrochloride GPCR/G Protein Sigma receptor inhibitor inhibit