S1R agonist 2 hydrochloride

Name: S1R agonist 2 hydrochloride
Brand: TargetMol
SKU: T78087
Rating: 4.5 (1 reviews)

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Catalog No. T78087

Compound 8b hydrochloride, a selective S1R agonist, exhibits affinity with K i s of 1.1 nM for S1R and 88 nM for S2R. It demonstrates neuroprotective effects against ROS and NMDA-induced neurotoxicity [1].

S1R agonist 2 hydrochloride

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Catalog No. T78087

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$97	5 days	5 days

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Product Introduction

Bioactivity

Description	Compound 8b hydrochloride, a selective S1R agonist, exhibits affinity with K i s of 1.1 nM for S1R and 88 nM for S2R. It demonstrates neuroprotective effects against ROS and NMDA-induced neurotoxicity [1].
In vitro	S1R agonist 2 (Compound 8b; 0.1-5 μM) hydrochloride significantly enhances NGF-induced neurite outgrowth in a dose-dependent manner; at 1 μM over 24 hours, it markedly inhibits Rotenone-induced cellular damage in SHSY5Y cells. Additionally, it offers neuroprotection against NMDA stimulation in SHSY5Y cells at 0.1-5 μM over 24 hours. This compound exhibits no cytotoxicity in A549, LoVo, and Panc-1 cells at varying concentrations (0-10 μM) and durations (24-72 h) [1].
In vivo	Compound 8b (S1R agonist 2; 0.1-50 μM; 120 h) hydrochloride at a concentration of 10 μM does not induce embryonic mortality (100% survival of embryos), yet at the highest dosage (50 μM), it induces death in all embryos [1].

Chemical Properties

Molecular Weight	345.91
Formula	C₂₁H₂₈ClNO

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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You can also refer to dose conversion for different animals. More Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc