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FM19G11

Name: FM19G11
Brand: TargetMol
SKU: T36711
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T36711Cas No. 329932-55-0

Alias HIF-1alpha/2alpha Inhibitor, FM19G11

FM19G11 is an inhibitor of hypoxia inducible factor (HIF) α-subunit (IC50 = 80 nM in hypoxia induced luciferase assay).

FM19G11

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Purity: 99.70%

Catalog No. T36711Alias HIF-1alpha/2alpha Inhibitor, FM19G11Cas No. 329932-55-0

FM19G11 is an inhibitor of hypoxia inducible factor (HIF) α-subunit (IC50 = 80 nM in hypoxia induced luciferase assay).

Pack Size	Price	Availability
1 mg	$43	In Stock
5 mg	$97	In Stock
10 mg	$178	In Stock
25 mg	$313	In Stock
50 mg	$493	In Stock
100 mg	$793	In Stock

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Purity:99.70%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	FM19G11 is an inhibitor of hypoxia inducible factor (HIF) α-subunit (IC50 = 80 nM in hypoxia induced luciferase assay).
In vitro	FM19G11 (500 nM) promotes oligodendrocyte differentiation under hypoxic conditions[1]. FM19G11 (300 nM) significantly enhances the pro-apoptotic effect of temozolomide, whereas FM19G11 does not induce apoptosis. In hypoxic GBM-XD, hypoxic T98G, and normoxic T98G cells, FM19G11 (300 nM) significantly inhibited the mRNA level of O6-methylguanine DNA-methyltransferase via the HIF-1α pathway[3].
In vivo	Intramedullary injection of FM19G11 improves locomotion in severe spinal cord injury and induces the expression of GAP43 and RIP at the injury[2].
Synonyms	HIF-1alpha/2alpha Inhibitor, FM19G11

Chemical Properties

Molecular Weight	463.4
Formula	C₂₃H₁₇N₃O₈
Cas No.	329932-55-0
Smiles	Cc1ccc(cc1)C(=O)COC(=O)c1cccc(NC(=O)c2ccc(cc2[N+]([O-])=O)[N+]([O-])=O)c1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (194.2 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1580 mL	10.7898 mL	21.5796 mL	107.8981 mL
5 mM	0.4316 mL	2.1580 mL	4.3159 mL	21.5796 mL
10 mM	0.2158 mL	1.0790 mL	2.1580 mL	10.7898 mL
20 mM	0.1079 mL	0.5395 mL	1.0790 mL	5.3949 mL
50 mM	0.0432 mL	0.2158 mL	0.4316 mL	2.1580 mL
100 mM	0.0216 mL	0.1079 mL	0.2158 mL	1.0790 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc