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Pomalidomide-PEG4-C-COOH

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Catalog No. T17325Cas No. 2097938-44-6
Alias E3 Ligase Ligand-Linker Conjugates 1, Cereblon Ligand -Linker Conjugates 1

Pomalidomide-PEG4-C-COOH (E3 Ligase Ligand-Linker Conjugates 1) is a synthesized E3 ligase ligand-linker conjugate that combines the Pomalidomide-based cereblon ligand and 4-unit PEG linker used in PROTAC technology.

Pomalidomide-PEG4-C-COOH

Pomalidomide-PEG4-C-COOH

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Purity: 96%
Catalog No. T17325Alias E3 Ligase Ligand-Linker Conjugates 1, Cereblon Ligand -Linker Conjugates 1Cas No. 2097938-44-6
Pomalidomide-PEG4-C-COOH (E3 Ligase Ligand-Linker Conjugates 1) is a synthesized E3 ligase ligand-linker conjugate that combines the Pomalidomide-based cereblon ligand and 4-unit PEG linker used in PROTAC technology.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$30-In Stock
5 mg$64-In Stock
10 mg$98-In Stock
25 mg$179-In Stock
50 mg$263-In Stock
100 mg$372-In Stock
200 mg$548-In Stock
1 mL x 10 mM (in DMSO)$87-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:96%
Appearance:Oil
Color:Yellow
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Product Introduction

Bioactivity
Description
Pomalidomide-PEG4-C-COOH (E3 Ligase Ligand-Linker Conjugates 1) is a synthesized E3 ligase ligand-linker conjugate that combines the Pomalidomide-based cereblon ligand and 4-unit PEG linker used in PROTAC technology.
SynonymsE3 Ligase Ligand-Linker Conjugates 1, Cereblon Ligand -Linker Conjugates 1
Chemical Properties
Molecular Weight507.49
FormulaC23H29N3O10
Cas No.2097938-44-6
SmilesO=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2NCCOCCOCCOCCOCC(O)=O
Relative Density.1.410 g/cm3 (Predicted)
Storage & Solubility Information
Storagekeep away from direct sunlight | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
Ethanol: 25 mg/mL (49.26 mM), Sonication is recommended.
DMSO: 50 mg/mL (98.52 mM), Sonication is recommended.
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM1.9705 mL9.8524 mL19.7048 mL98.5241 mL
5 mM0.3941 mL1.9705 mL3.9410 mL19.7048 mL
10 mM0.1970 mL0.9852 mL1.9705 mL9.8524 mL
20 mM0.0985 mL0.4926 mL0.9852 mL4.9262 mL
DMSO
1mg5mg10mg50mg
50 mM0.0394 mL0.1970 mL0.3941 mL1.9705 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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