GITRL Protein, Human, Recombinant (mFc)

GITRL Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 40.9 kDa and the accession number is Q9UNG2.

Pack Size	Availability	Price/USD	Quantity
100 μg	5 days	$ 539.00
1 mg	5 days	$ 2,510.00

Pack Size

Availability

Price/USD

Quantity

100 μg

5 days

$ 539.00

1 mg

5 days

$ 2,510.00

Description

GITRL Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 40.9 kDa and the accession number is Q9UNG2.

Species	Human
Expression System	HEK293 Cells
Tag	C-mFc
Accession Number	Q9UNG2
Synonyms	TL6, GITRL, tumor necrosis factor (ligand) superfamily, member 18, AITRL, hGITRL
Construction	The Human TNFSF18 (NP_005083.3) (Gln72-Ser199) was expressed with the Fc region of Mouse IgG2a at the C-terminus.
Protein Purity	> 90 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.
Molecular Weight	40.9 kDa (predicted)

Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells.Cancer ImmunotherapyCo-stimulatory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint TargetsImmunotherapyTargeted Therapy