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TFAP

Name: TFAP
Brand: TargetMol
SKU: T4643
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4643Cas No. 1011244-68-0

Alias N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide

TFAP (N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide) is a selective cyclooxygenase-1 (COX-1) inhibitor

TFAP

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Purity: 99.87%

Catalog No. T4643Alias N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamideCas No. 1011244-68-0

TFAP (N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide) is a selective cyclooxygenase-1 (COX-1) inhibitor

Pack Size	Price	Availability
5 mg	$43	In Stock
10 mg	$68	In Stock
25 mg	$131	In Stock
50 mg	$238	In Stock
100 mg	$353	In Stock
200 mg	$493	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock

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Batch Information

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Purity:99.87%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	TFAP (N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide) is a selective cyclooxygenase-1 (COX-1) inhibitor
Targets&IC50	COX-1:0.8 μM
In vitro	TFAP is a selective cyclooxygenase-1 (COX-1) inhibitor with an IC50 of 0.8 μM and an IC50 greater than 200 μM against [COX-2].
Synonyms	N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide

Chemical Properties

Molecular Weight	281.23
Formula	C₁₃H₁₀F₃N₃O
Cas No.	1011244-68-0
Smiles	Nc1ccc(NC(=O)c2ccc(cc2)C(F)(F)F)nc1
Relative Density.	1.425 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (177.79 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5558 mL	17.7790 mL	35.5581 mL	177.7904 mL
5 mM	0.7112 mL	3.5558 mL	7.1116 mL	35.5581 mL
10 mM	0.3556 mL	1.7779 mL	3.5558 mL	17.7790 mL
20 mM	0.1778 mL	0.8890 mL	1.7779 mL	8.8895 mL
50 mM	0.0711 mL	0.3556 mL	0.7112 mL	3.5558 mL
100 mM	0.0356 mL	0.1778 mL	0.3556 mL	1.7779 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc