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Chlorprothixene hydrochloride
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Catalog No. T0074LCas No. 6469-93-8
Alias Truxal hydrochloride, NSC 78193, NSC 56379, NSC 169899, Minithixen hydrochloride, Minithixen
Chlorprothixene hydrochloride (Truxal hydrochloride) brings strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors. Chlorprothixene hydrochloride s a typical antipsychotic drug of the thioxanthene (tricyclic) class.
Chlorprothixene hydrochloride
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Purity: 99.97%
Catalog No. T0074LAlias Truxal hydrochloride, NSC 78193, NSC 56379, NSC 169899, Minithixen hydrochloride, MinithixenCas No. 6469-93-8
Chlorprothixene hydrochloride (Truxal hydrochloride) brings strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors. Chlorprothixene hydrochloride s a typical antipsychotic drug of the thioxanthene (tricyclic) class.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 100 mg | $31 | In Stock | In Stock | |
| 200 mg | $49 | - | In Stock | |
| 500 mg | $99 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $39 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.97%
Appearance:Solid
Color:White
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Product Introduction
Chlorprothixene hydrochloride AI Summary
Chlorprothixene hydrochloride demonstrates a wide range of bioactivities. It shows antiplasmodial activity against various strains of *Plasmodium falciparum*, with IC50 values ranging from 5011.87 nM to 12589.25 nM after 72 hours by SYBR green assay. In terms of bacterial inhibition, it exhibits inhibitory effects on AmpC Beta-Lactamase with a potency of 354.8 nM and against the PhoP region in *Salmonella typhi* with IC50 values ranging from 30110.0 nM to 86192.0 nM, alongside showing cytotoxicity to the PhoP region with an EC50 of 10090.0 nM. Additionally, it has notable inhibition activity against OATP1B3 and OATP1B1 transporters in CHO cells.
Regarding antifungal properties, Chlorprothixene hydrochloride shows antibiofilm activity against *Candida albicans* with a MBIC50 value of 17.0 uM after 24 hours. It also exhibits antiviral activity by inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 cells (12.12% inhibition at 10 uM after 48 hours) and VERO-6 cells (0.27% inhibition under the same conditions). Moreover, it exhibits 7.851% inhibition of the SARS-CoV-2 3CL-Pro protease at a 20 µM concentration.
Furthermore, Chlorprothixene hydrochloride displays potential inhibitory activities in several other biological systems, including chronic active B-Cell receptor signaling, BAZ2B, malarial parasite plastid, TGF-β, cell surface uPA generation, Hepatitis C Virus (HCV), DNA re-replication in SW480 colon adenocarcinoma cells, ATXN expression, and as a GLP-1 Receptor Inverse Agonist, each with varying degrees of potency..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Chlorprothixene hydrochloride (Truxal hydrochloride) brings strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors. Chlorprothixene hydrochloride s a typical antipsychotic drug of the thioxanthene (tricyclic) class. |
| Targets&IC50 | D5 receptor (human):9 nM (Ki), D2 receptor (human):2.96 nM (Ki), D3 receptor (human):4.56 nM (Ki), H1 receptor (human):3.75 nM (Ki), D1 receptor (human):18 nM (Ki) |
| Synonyms | Truxal hydrochloride, NSC 78193, NSC 56379, NSC 169899, Minithixen hydrochloride, Minithixen |
| Molecular Weight | 352.32 |
| Formula | C18H18ClNS·HCl |
| Cas No. | 6469-93-8 |
| Smiles | Cl.CN(C)CC\C=C1\c2ccccc2Sc2ccc(Cl)cc12 |
| Relative Density. | no data available |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 10 mg/mL (28.38 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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