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Anti-SKOR2 Polyclonal Antibody

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Catalog No. TMAB-12826

Anti-SKOR2 Polyclonal Antibody is a Rabbit antibody targeting SKOR2. Anti-SKOR2 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.

Anti-SKOR2 Polyclonal Antibody

Anti-SKOR2 Polyclonal Antibody

😃Good
Catalog No. TMAB-12826
Anti-SKOR2 Polyclonal Antibody is a Rabbit antibody targeting SKOR2. Anti-SKOR2 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2217-10 days7-10 days
100 μL$3747-10 days7-10 days
200 μL$5277-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-SKOR2 Polyclonal Antibody is a Rabbit antibody targeting SKOR2. Anti-SKOR2 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
Reactivity
Mouse,Rat (predicted:Human,Dog,Cow,Sheep)
Application
IHC-P
IHC-Fr
IF
Recommended Dose
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationNucleus. Cytoplasm.
Tissue SpecificityExpressed in cerebellum, spinal cord and testis. Isoform 2 is present in cerebellum (at protein level).
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundThe sloan kettering virus (Ski) family of nuclear oncoproteins act as transcriptional regulators of TGF-β by interacting directly with SMAD proteins. Fussel-18 (functional Smad-suppressing element on chromosome 18), also known as SKOR2 (Ski family transcriptional corepressor 2), LBX1 corepressor 1-like protein, ladybird homeobox corepressor 1-like protein or CORL2, is a 1,001 amino acid protein that belongs to the Ski family. Localizing to nucleus as well as cytoplasm, Fussel-18 is expressed in cerebellum, spinal cord and testis. Fussel-18 acts as an antagonist to TGF-β in the nervous system, possibly by functioning as a transcriptional repressor of SMAD2 and SMAD3. Existing as two alternatively spliced isoforms, the gene encoding Fussel-18 maps to human chromosome 18q21.1 and mouse chromosome 18 E3.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human SKOR2
Antigen Species
Human
Gene Name
SKOR2
Gene ID
652991
Protein Name
SKI family transcriptional corepressor 2
Uniprot ID
Q2VWA4
Function
Exhibits transcriptional repressor activity (By similarity). Acts as a TGF-beta antagonist in the nervous system.
Chemical Properties
Molecular WeightTheoretical: 104 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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