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Chlorthal-dimethyl

Name: Chlorthal-dimethyl
Brand: TargetMol
SKU: T14954
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14954Cas No. 1861-32-1

Alias Dimethyl tetrachloroterephthalate

Chlorthal-dimethyl is used as a pesticide intermediate.

Chlorthal-dimethyl

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Catalog No. T14954Alias Dimethyl tetrachloroterephthalateCas No. 1861-32-1

Chlorthal-dimethyl is used as a pesticide intermediate.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$42	-	In Stock
10 g	$59	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Appearance:Solid

Color:Yellow

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Product Introduction

Chlorthal-dimethyl AI Summary

Chlorthal-dimethyl has bioactivities related to various signaling pathways, herbicidal properties, and viral inhibition. It is a potent agonist of peroxisome proliferator-activated receptor gamma signaling with a potency of 10,000 nM and an agonist of the antioxidant response element (ARE) signaling pathway with a potency of 54,482.7 nM. Additionally, it activates the human pregnane X receptor (PXR) signaling pathway with a potency of 70,794.6 nM and is identified as a gametocytocidal compound with a potency of 63,095.7 nM. Remarkably, it shows inhibition of Ebola virus entry across different screening channels with AC50 values of 31.62 uM, 3.981 uM, 1.413 uM, 31,622.8 nM, and 1,412.5 nM. In the context of herbicidal activity, Chlorthal-dimethyl is effective against Cyperus rotundus, Malva sylvestris, and Chenopodium murale, leading to significant reductions in total dry and fresh weight when applied at 7 kg/ha before seed sowing, and also demonstrates phytotoxicity in Allium cepa seedlings at the same application rate. Furthermore, it inhibits the uptake of sodium fluorescein in both OATP1B1-transfected CHO cells and OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM, with inhibition percentages of 103.47% in OATP1B1 cells and 106.64% in OATP1B3 cells..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Chlorthal-dimethyl is used as a pesticide intermediate.
Synonyms	Dimethyl tetrachloroterephthalate

Chemical Properties

Molecular Weight	331.96
Formula	C₁₀H₆Cl₄O₄
Cas No.	1861-32-1
Smiles	COC(=O)C1=C(Cl)C(Cl)=C(C(=O)OC)C(Cl)=C1Cl
Relative Density.	1.6496 g/cm3 (Estimated)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (60.25 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0124 mL	15.0621 mL	30.1241 mL	150.6206 mL
5 mM	0.6025 mL	3.0124 mL	6.0248 mL	30.1241 mL
10 mM	0.3012 mL	1.5062 mL	3.0124 mL	15.0621 mL
20 mM	0.1506 mL	0.7531 mL	1.5062 mL	7.5310 mL
50 mM	0.0602 mL	0.3012 mL	0.6025 mL	3.0124 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc