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BCL6-IN-3

Name: BCL6-IN-3
Brand: TargetMol
SKU: T10487
Price: 1130 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10487Cas No. 2253878-44-1

BCL6-IN-3 is a potent BCL6 inhibitor with GI50 of 70 nM in SU-DHL4 cells. BCL6-in-3 regulates cell activation, differentiation, DNA damage and apoptosis, and has antitumor activity.

BCL6-IN-3

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Purity: 98.17%

Catalog No. T10487Cas No. 2253878-44-1

BCL6-IN-3 is a potent BCL6 inhibitor with GI50 of 70 nM in SU-DHL4 cells. BCL6-in-3 regulates cell activation, differentiation, DNA damage and apoptosis, and has antitumor activity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$117	In Stock	In Stock
5 mg	$268	In Stock	In Stock
10 mg	$395	In Stock	In Stock
25 mg	$592	In Stock	In Stock
50 mg	$828	In Stock	In Stock
100 mg	$1,130	In Stock	In Stock
500 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$412	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.17%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

BCL6-IN-3 AI Summary

BCL6-IN-3 demonstrates significant potential as a BCL6 inhibitor, exhibiting an IC50 of 520.0 nM for human BCL6 inhibition. It effectively induces degradation of BCL6 in various human cell lines, with DC50 values ranging between 0.049 µM and 0.09 µM. The compound shows antiproliferative activity against multiple human cell lines, with GI50 values from 35.0 nM to 1600.0 nM. It also displays good kinetic solubility in HEPES and PBS buffers and possesses a metabolic stability with a clearance rate of 78.0 mL·min⁻¹·g⁻¹ in CD-1 mouse liver microsomes. BCL6-IN-3 has a log D value of 4.3, indicating its lipophilicity, and shows good oral bioavailability at 54.0% in BALB/c mice. Additional pharmacokinetic parameters include a short half-life of 1.4 hours and a moderate volume of distribution at steady state of 2.1 L·kg⁻¹. Furthermore, the compound has high protein binding with 99.96% bound to plasma proteins in BALB/c mice. These attributes highlight BCL6-IN-3's potential in therapeutic applications targeting BCL6 with promising bioavailability and solubility profiles..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	BCL6-IN-3 is a potent BCL6 inhibitor with GI50 of 70 nM in SU-DHL4 cells. BCL6-in-3 regulates cell activation, differentiation, DNA damage and apoptosis, and has antitumor activity.
Targets&IC50	Proliferation (SU-DHL4 cells):70 nM (GI50)

Chemical Properties

Molecular Weight	508.99
Formula	C₂₄H₃₁ClF₂N₆O₂
Cas No.	2253878-44-1
Smiles	C(CC(C)(C)O)N1C=2C(N(C)C1=O)=CC=C(NC3=NC(=NC=C3Cl)N4C[C@H](C)C(F)(F)[C@H](C)C4)C2
Relative Density.	1.38 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 180 mg/mL (353.64 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9647 mL	9.8234 mL	19.6468 mL	98.2338 mL
5 mM	0.3929 mL	1.9647 mL	3.9294 mL	19.6468 mL
10 mM	0.1965 mL	0.9823 mL	1.9647 mL	9.8234 mL
20 mM	0.0982 mL	0.4912 mL	0.9823 mL	4.9117 mL
50 mM	0.0393 mL	0.1965 mL	0.3929 mL	1.9647 mL
100 mM	0.0196 mL	0.0982 mL	0.1965 mL	0.9823 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc