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BCL6-IN-3

Name: BCL6-IN-3
Brand: TargetMol
SKU: T10487
Price: 1130 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10487Cas No. 2253878-44-1

BCL6-IN-3 is a potent BCL6 inhibitor with GI50 of 70 nM in SU-DHL4 cells. BCL6-in-3 regulates cell activation, differentiation, DNA damage and apoptosis, and has antitumor activity.

BCL6-IN-3

🥰Excellent

Purity: 98.17%

Catalog No. T10487Cas No. 2253878-44-1

BCL6-IN-3 is a potent BCL6 inhibitor with GI50 of 70 nM in SU-DHL4 cells. BCL6-in-3 regulates cell activation, differentiation, DNA damage and apoptosis, and has antitumor activity.

Pack Size	Price	Availability
1 mg	$117	In Stock
5 mg	$268	In Stock
10 mg	$395	In Stock
25 mg	$592	In Stock
50 mg	$828	In Stock
100 mg	$1,130	In Stock
500 mg	Preferential	In Stock
1 mL x 10 mM (in DMSO)	$412	In Stock

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Batch Information

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Purity:98.17%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	BCL6-IN-3 is a potent BCL6 inhibitor with GI50 of 70 nM in SU-DHL4 cells. BCL6-in-3 regulates cell activation, differentiation, DNA damage and apoptosis, and has antitumor activity.
Targets&IC50	Proliferation (SU-DHL4 cells):70 nM (GI50)

Chemical Properties

Molecular Weight	508.99
Formula	C₂₄H₃₁ClF₂N₆O₂
Cas No.	2253878-44-1
Smiles	C(CC(C)(C)O)N1C=2C(N(C)C1=O)=CC=C(NC3=NC(=NC=C3Cl)N4C[C@H](C)C(F)(F)[C@H](C)C4)C2
Relative Density.	1.38 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 180 mg/mL (353.64 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9647 mL	9.8234 mL	19.6468 mL	98.2338 mL
5 mM	0.3929 mL	1.9647 mL	3.9294 mL	19.6468 mL
10 mM	0.1965 mL	0.9823 mL	1.9647 mL	9.8234 mL
20 mM	0.0982 mL	0.4912 mL	0.9823 mL	4.9117 mL
50 mM	0.0393 mL	0.1965 mL	0.3929 mL	1.9647 mL
100 mM	0.0196 mL	0.0982 mL	0.1965 mL	0.9823 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc