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Nampt-IN-5

Name: Nampt-IN-5
Brand: TargetMol
SKU: T12171
Price: 74 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12171Cas No. 2380013-17-0

Nampt-IN-5 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (NAMPT).

Nampt-IN-5

🥰Excellent

Purity: 99.30%

Catalog No. T12171Cas No. 2380013-17-0

Nampt-IN-5 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (NAMPT).

Pack Size	Price	Availability
1 mg	$74	In Stock
5 mg	$158	In Stock
10 mg	$278	In Stock
25 mg	$442	In Stock
50 mg	$592	In Stock
100 mg	$816	In Stock
200 mg	$1,080	In Stock
1 mL x 10 mM (in DMSO)	$173	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.30%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Nampt-IN-5 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (NAMPT).
Targets&IC50	CYP3:0.7 nM
In vitro	Nampt-IN-5 shows a good ADME data: mouse microsomal clearance, CYP3A4 inhibition value (0.75 μM), Sol6.8: 0.056 mM; MDCK Papp AB: 18.6.Nampt-IN-5 has cellular IC50s of 0.7 nM and 3.9 nM against A2780 and COR-L23, respectively in CellTiterGlo (CTG) assays[1].

Chemical Properties

Molecular Weight	427.5
Formula	C₂₅H₂₅N₅O₂
Cas No.	2380013-17-0
Smiles	CCOc1nc2ccccc2n1Cc1ccc(NC(=O)N2CC(C2)c2cccnc2)cc1
Relative Density.	1.29 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 48 mg/mL (112.28 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.68 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3392 mL	11.6959 mL	23.3918 mL	116.9591 mL
5 mM	0.4678 mL	2.3392 mL	4.6784 mL	23.3918 mL
10 mM	0.2339 mL	1.1696 mL	2.3392 mL	11.6959 mL
20 mM	0.1170 mL	0.5848 mL	1.1696 mL	5.8480 mL
50 mM	0.0468 mL	0.2339 mL	0.4678 mL	2.3392 mL
100 mM	0.0234 mL	0.1170 mL	0.2339 mL	1.1696 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc